Advancing Open Science
for more than 25 years
Supporting academic communities
since 1996
 
16 pages, 4137 KiB  
Article
Flow Pattern and Escape Hazards of People from Flood Intrusion into the Staircase of Underground Spaces with Multiple Rest Platforms
by Zhiyu Lin, Shengbin Hu and Hang Lin
Buildings 2024, 14(4), 941; https://doi.org/10.3390/buildings14040941 (registering DOI) - 29 Mar 2024
Abstract
While urban underground space is being built and developed at a high speed, urban flooding is also occurring gradually and frequently. Urban water, in many disasters, has intruded into underground spaces, such as subway stations, often leading to serious casualties, in which it [...] Read more.
While urban underground space is being built and developed at a high speed, urban flooding is also occurring gradually and frequently. Urban water, in many disasters, has intruded into underground spaces, such as subway stations, often leading to serious casualties, in which it is crucial for people to be able to escape from the staircases. In order to enable and guide the escape of people in underground floods, a staircase model with multiple rest platforms, applicable to common entrance and exit staircase forms, was constructed. The realizable k-ε turbulence model, coupled with a volume of fluid (VOF) method, was used to simulate and analyze the flow patterns when floods of various heights intrude into the structure. The effects of rest platform settings on the ejection phenomena and flow velocity changes in flood flows were summarized. The change rule of flood flow velocity on the stairs under different flood heights and stair heights was summarized, and a linear relationship between the peak flood flow velocity and the location of the peak flow velocity point on each flight of stairs was derived. Combined with the formula of the critical conditions for people to escape upwards in the flood, the proposed escape conditions for staircases with multiple rest platforms were proposed, which provide a basis for guiding the evacuation of people in times of disaster. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
10 pages, 240 KiB  
Article
Church Governance—A Philosophical Approach to a Theological Challenge in an Anglican Context
by Peter D. G. Richards
Religions 2024, 15(4), 427; https://doi.org/10.3390/rel15040427 (registering DOI) - 29 Mar 2024
Abstract
Church governance is not often debated within a philosophical or theological sphere. This is perhaps because church governance has been part of tradition since Constantine and the initial Greek philosophical world view of sovereignty and hierarchy. Such a stance has led towards a [...] Read more.
Church governance is not often debated within a philosophical or theological sphere. This is perhaps because church governance has been part of tradition since Constantine and the initial Greek philosophical world view of sovereignty and hierarchy. Such a stance has led towards a managerial mindset that follows and conforms to the world, which plays out within the Anglican polity in the setting of an adversarial parliamentary style synod. This style encourages bounded communities of power that often refute the burgeoning inspirations of the Spirit. In changing the underlying theological basis of such a stance, by invoking the understanding of an undeniable community in the singularity of the Triune God, governance becomes more open. Engaging with, primarily, Agamben but also others from philosophy, a new viewpoint is presented to challenge the manner through which tradition is wielded as the only possibility. In seeing through a differing lens, communities can be conceived as both porous and interconnected, thus allowing the body of Christ to respond with transformative action as opposed to a continuum of conformance with secular legality. In this manner, the bishop’s role may become more centralised towards a Eucharistic one, as opposed to the managerial mindset and role, to enhance the possibilities of God’s love. This then removes the need for a hierarchy driven by a sovereign mindset that tradition bolsters, whilst maintaining loving and authoritative oversight that tradition suggests. Full article
(This article belongs to the Special Issue Continental Philosophy and Christian Beliefs)
11 pages, 239 KiB  
Article
Association of Urine (pH < 5.5) with Community Periodontal Index (CPI) and the Number of Remaining Teeth in Korean Adults: A Cross-Sectional Study Using Data from Korea National Health and Nutrition Examination Survey 2016–2018
by Su-Yeon Hwang and Jung-Eun Park
Healthcare 2024, 12(7), 740; https://doi.org/10.3390/healthcare12070740 (registering DOI) - 29 Mar 2024
Abstract
This study aims to determine the association between UpH (<5.5), Community Periodontal Index (CPI), and the number of remaining teeth—cumulative indicators of oral health—using data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES, 2016–2018), which represents the Korean population. [...] Read more.
This study aims to determine the association between UpH (<5.5), Community Periodontal Index (CPI), and the number of remaining teeth—cumulative indicators of oral health—using data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES, 2016–2018), which represents the Korean population. Data from 12,689 adults aged 19 years and older who had periodontal examinations were analyzed. Logistic regression analysis was performed after adjusting for demographic, health, and health-related behavioral factors as covariates to determine the association between UpH, CPI, and the number of remaining teeth. This study found that UpH (<5.5) was associated with CPI and the number of remaining teeth. For UpH (<5.5), the odds ratio for CPI (≥4 mm) was 1.19 times (95% CI: 1.06–1.33). The risk of tooth loss was 1.25 times (95% CI: 1.06–1.48) for those with 0–19 remaining teeth and 1.20 times (95% CI: 1.07–1.34) for those with 20–27 teeth. The results revealed an association between UpH, CPI, and the number of remaining teeth. However, further longitudinal research on UpH and oral status is necessary. Full article
(This article belongs to the Special Issue Oral Health Care and Services for Patients)
15 pages, 3045 KiB  
Article
Transport Model of Rare Earth Elements in Weathering Crusts during Electrokinetic Mining
by Gaofeng Wang, Bowen Ling, Xiaoliang Liang, Jie Xu, Shichang Kang, Jingming Wei, Wei Tan, Runliang Zhu, Jianxi Zhu and Hongping He
Minerals 2024, 14(4), 360; https://doi.org/10.3390/min14040360 (registering DOI) - 29 Mar 2024
Abstract
Electrokinetic mining (EKM) is a novel method for rare earth element (REE) mining that can achieve green and efficient recovery of REEs. However, as yet, there is no accurate model for describing the electrokinetic transport of REEs in weathering crusts, and this hinders [...] Read more.
Electrokinetic mining (EKM) is a novel method for rare earth element (REE) mining that can achieve green and efficient recovery of REEs. However, as yet, there is no accurate model for describing the electrokinetic transport of REEs in weathering crusts, and this hinders the wider application of EKM. The conventional model fails to capture the microscale transport physics occurring in the nanochannels that exist ubiquitously in weathering crusts. Consequently, the existing models cannot distinguish the mobilities of different REEs. Here, we report a new model for a more faithful description of the electrokinetic transport of REEs in weathering crusts that considers the ionic size, which has previously been neglected. We reveal that the electrokinetic transport of heavy REEs (HREEs) is faster than that of light REEs (LREEs) in weathering crusts, which is contrary to the predictions of conventional models. Our model was validated experimentally by measurements of the electrokinetic transport of two LREEs (La and Sm) and an HREE (Er) in weathering crusts. The speed of electrokinetic transport follows the order Er > Sm > La. Our findings suggest that the ionic size is a non-negligible factor affecting the electrokinetic transport of REEs in weathering crusts containing nanochannels. This work offers a constitutive model to describe the electrokinetic transport of REEs in weathering crusts, which promotes both theoretical developments and practical applications of EKM. Full article
(This article belongs to the Special Issue Green and Efficient Recovery/Extraction of Rare Earth Resources)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
15 pages, 4489 KiB  
Article
Influence of the Long-Term Application of Management Practices (Tillage, Cover Crop and Glyphosate) on Greenhouse Gas Emissions and Soil Physical Properties
by Modupe Olufemi Doyeni, Skaidre Suproniene, Agne Versuliene, Loreta Meskauskiene and Grazina Kadziene
Sustainability 2024, 16(7), 2859; https://doi.org/10.3390/su16072859 (registering DOI) - 29 Mar 2024
Abstract
Soil treatments have a significant influence on the agricultural and environmental productivity of agricultural practices. Arable lands are one of the sources of greenhouse gas emissions (GHG) that are influenced by the chemical and physical properties of the soil and are an essential [...] Read more.
Soil treatments have a significant influence on the agricultural and environmental productivity of agricultural practices. Arable lands are one of the sources of greenhouse gas emissions (GHG) that are influenced by the chemical and physical properties of the soil and are an essential contributor to climate change. We aim to evaluate the long-term management of agricultural practices, such as different tillage systems, cover crops, and glyphosate, on GHG emissions and soil physical properties. The field trial involved three tillage systems (conventional tillage (CT), reduced tillage (RT), and no-tillage (NT)), along with variations in cover cropping (with and without cover crops) and glyphosate application (with and without glyphosate). These treatments were implemented during the cultivation of oilseed rape in 2022 as part of a cropping sequence consisting of five crops: winter wheat; winter oilseed rape; spring wheat; spring barley; and field pea. Greenhouse gas emissions (carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O)) were directly measured using a closed static chamber system. Through the examination of these management techniques, the soil’s physical properties over the studied period were assessed for their impact on GHG fluxes. The findings of the study reveal that N2O emissions were relatively low during the first month of measurement, with significant differences (p < 0.05) observed in the interaction between cover crop and glyphosate treatments. Additionally, N2O emissions were notably elevated in the reduced (0.079 µg m−2 h−1) and conventional tillage (0.097 µg m−2 h−1) treatments at the second month of measurement. Regarding CH4, increased emissions were observed in the reduced tillage and cover crop treatments. CO2 emissions exhibited variability across all of the investigated treatments. Notably, GHG fluxes spiked at the second measurement, signifying the maximum uptake of nutrients by the main plants during the growth phase. Greenhouse gas emissions leveled off across all of the treatments following the harvest, marking the end of the cultivation period. The influence of the deployed techniques varied across the determined physical parameters of the soil. The incorporation of cover crops contributed to improved water content and, further, to electrical conductivity. Glyphosate use showed no direct impact on physical properties of the soil while the different tillage treatments had varying effects on the distribution of the physical properties of the soil with respect to the degree of disturbance or tillage-induced changes. Additionally, GHG emissions were strongly correlated with precipitation at one week and two weeks before sampling, except for CO2, which showed a weaker correlation at two weeks before GHG sampling. The findings indicate that reduced and conventional tillage methods might adversely affect greenhouse gas emissions and plant functionality, particularly concerning nutrient release and uptake, especially in temperate climate conditions. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">
15 pages, 1020 KiB  
Review
Lower Urinary Tract Infections: An Approach for Greek Community Health Practitioners
by Diamantis Klimentidis and Georgios Pappas
Acta Microbiol. Hell. 2024, 69(2), 50-64; https://doi.org/10.3390/amh69020007 (registering DOI) - 29 Mar 2024
Abstract
Urinary tract infections (UTIs) cause a significant infectious burden in the community and demand a coordinated approach from all first-line health professionals. Uncomplicated UTIs refer to infections in non-pregnant females without any underlying localized or generalized pathology, diagnosed through history by the presence [...] Read more.
Urinary tract infections (UTIs) cause a significant infectious burden in the community and demand a coordinated approach from all first-line health professionals. Uncomplicated UTIs refer to infections in non-pregnant females without any underlying localized or generalized pathology, diagnosed through history by the presence of specific local symptoms and in the absence of systemic ones like fever. Uncomplicated UTIs are usually caused by Escherichia coli species; thus, empirical antibiotic treatment can be immediately initiated. A percentage of patients can experience a resolution of symptoms without therapy; however, this “wait and observe” approach is supported only by the relevant British guidelines. There are limited quality studies in the literature on adjuvant treatment options; these can include BNO 145, a phytotherapeutic medicine, and XHP, a medical technology product. Despite being licensed by the European Medicines Agency on the basis of traditional use, there is inadequate support in the medical literature for the use of cranberry extracts and Arctostaphylos uva-ursi extracts. The use of antibiotics is associated with higher response rates and urine culture sterilization as well as lower recurrence/relapse rates; on the other hand, side effect rates are also higher. In choosing the proper empirical antibiotic therapy, one has to take into account individual patient characteristics and community resistance patterns as well as the antimicrobial resistance pressure exerted by the wide use of a specific antibiotic. There is a need for a common framework through which all frontline health practitioners should operate when faced with a case of uncomplicated UTI. In Greece, there are three different guidelines for UTI treatment, developed by the Ministry of Health, the National Organization for Medicines, and the Hellenic Society for Infectious Diseases. The authors of the present study aim at synthesizing these guidelines as well as relevant guidelines from international scientific or other national regulatory organizations while taking into account local resistance patterns. The authors propose the first-line use of either fosfomycin, nitrofurantoin, or pivmecillinam. The use of trimethoprim/sulfamethoxazole is discouraged due to increased resistance of Greek community E. coli isolates. Fluoroquinolone use should be avoided due to high E. coli community resistance (exceeding 20% for Greece), along with their unfavorable benefit/side effect balance in uncomplicated UTIs, as well as the overall community resistance pressure exerted by their use. A 5-day regimen remains superior to a 3-day one; the latter may be suitable for certain, not yet adequately characterized, patients. Full article
(This article belongs to the Special Issue Feature Papers in Medical Microbiology in 2024)
Show Figures

Figure 1

Full article ">
11 pages, 1257 KiB  
Article
Sensor-Based Quantitative Assessment of Children’s Fine Motor Competence: An Instrumented Version of the Placing Bricks Test
by Maria Cristina Bisi and Rita Stagni
Sensors 2024, 24(7), 2192; https://doi.org/10.3390/s24072192 (registering DOI) - 29 Mar 2024
Abstract
The assessment of fine motor competence plays a pivotal role in neuropsychological examinations for the identification of developmental deficits. Several tests have been proposed for the characterization of fine motor competence, with evaluation metrics primarily based on qualitative observation, limiting quantitative assessment to [...] Read more.
The assessment of fine motor competence plays a pivotal role in neuropsychological examinations for the identification of developmental deficits. Several tests have been proposed for the characterization of fine motor competence, with evaluation metrics primarily based on qualitative observation, limiting quantitative assessment to measures such as test durations. The Placing Bricks (PB) test evaluates fine motor competence across the lifespan, relying on the measurement of time to completion. The present study aims at instrumenting the PB test using wearable inertial sensors to complement PB standard assessment with reliable and objective process-oriented measures of performance. Fifty-four primary school children (27 6-year-olds and 27 7-year-olds) performed the PB according to standard protocol with their dominant and non-dominant hands, while wearing two tri-axial inertial sensors, one per wrist. An ad hoc algorithm based on the analysis of forearm angular velocity data was developed to automatically identify task events, and to quantify phases and their variability. The algorithm performance was tested against video recordings in data from five children. Cycle and Placing durations showed a strong agreement between IMU- and Video-derived measurements, with a mean difference <0.1 s, 95% confidence intervals <50% median phase duration, and very high positive correlation (ρ > 0.9). Analyzing the whole population, significant differences were found for age, as follows: six-year-olds exhibited longer cycle durations and higher variability, indicating a stage of development and potential differences in hand dominance; seven-year-olds demonstrated quicker and less variable performance, aligning with the expected maturation and the refined motor control associated with dominant hand training during the first year of school. The proposed sensor-based approach allowed the quantitative assessment of fine motor competence in children, providing a portable and rapid tool for monitoring developmental progress. Full article
(This article belongs to the Special Issue Movement Biomechanics Applications of Wearable Inertial Sensors)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">
17 pages, 13202 KiB  
Article
The Bacterial and Fungal Compositions in the Rhizosphere of Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. in a Typical Planting Region
by Fuqi Wang, Zilu Zhao, Yangyang Han, Shiying Li, Xinhua Bi, Shumeng Ren, Yingni Pan, Dongmei Wang and Xiaoqiu Liu
Microorganisms 2024, 12(4), 692; https://doi.org/10.3390/microorganisms12040692 (registering DOI) - 29 Mar 2024
Abstract
Asarum is a traditional Chinese medicinal plant, and its dried roots are commonly used as medicinal materials. Research into the traits of the bacteria and fungus in the Asarum rhizosphere and how they relate to the potency of medicinal plants is important. During [...] Read more.
Asarum is a traditional Chinese medicinal plant, and its dried roots are commonly used as medicinal materials. Research into the traits of the bacteria and fungus in the Asarum rhizosphere and how they relate to the potency of medicinal plants is important. During four cropping years and collecting months, we used ITS rRNA gene amplicon and sequencing to assess the population, diversity, and predominant kinds of bacteria and fungus in the rhizosphere of Asarum. HPLC was used to determine the three bioactive ingredients, namely asarinin, aristolochic acid I, and volatile oil. The mainly secondary metabolites of Asarum, relationships between microbial communities, soil physicochemical parameters, and possible influences on microbial communities owing to various cropping years and collecting months were all statistically examined. The cropping years and collecting months affected the abundance and diversity of rhizosphere bacteria and fungi, but the cropping year had a significant impact on the structures and compositions of the bacterial communities. The rhizosphere microorganisms were influenced by both the soil physicochemical properties and enzyme activities. Additionally, this study revealed that Trichoderma was positively correlated with the three bioactive ingredients of Asarum, while Tausonia showed entirely opposite results. Gibberella and Leptosphaeria demonstrated a significantly negative correlation with asarinin and violate oil, but they were weakly correlated with the aristolochic acid I content. This study revealed variations in the Asarum rhizosphere microorganism population, diversity, and dominant types across four cropping years and collecting months. The relationship between Asarum secondary metabolites, the soil physicochemical properties, enzyme activities, and rhizosphere microorganisms was discussed. Our results will guide the exploration of the soil characteristics and rhizosphere microorganisms’ structures by regulating the microbial community to enhance Asarum quality. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">
15 pages, 1500 KiB  
Review
Spirulina (Arthrospira platensis): Antiallergic Agent or Hidden Allergen? A Literature Review
by Weronika Gromek, Natalia Ko?dej, Marcin Kurowski and Emilia Majsiak
Foods 2024, 13(7), 1052; https://doi.org/10.3390/foods13071052 (registering DOI) - 29 Mar 2024
Abstract
Presently, there has been an increase in the consumption of the blue–green microalga–spirulina (Arthrospira species), which dominates 99.5% of the total world production of microalgae. Primarily sold as a dietary supplement, it is also incorporated into snacks, pasta, cookies, and bread. Owing [...] Read more.
Presently, there has been an increase in the consumption of the blue–green microalga–spirulina (Arthrospira species), which dominates 99.5% of the total world production of microalgae. Primarily sold as a dietary supplement, it is also incorporated into snacks, pasta, cookies, and bread. Owing to its nutrient abundance, spirulina has a variety of potential applications. Extensive studies have been conducted on the health benefits of spirulina, but its safety in terms of allergy has received limited attention. Therefore, to bridge this knowledge deficit, this review aimed to evaluate the allergenic and antiallergic potential of spirulina. In the PubMed and Scopus databases using words related to allergy, we attempted to detect papers on hypersensitivity to spirulina. A total of 128 records were identified, of which 49 were screened. Ultimately, in this review, we analyzed four case studies, encompassing a total of five patients with allergies to spirulina. We assessed the severity of allergic reactions following World Allergy Organization (WAO) Anaphylaxis Guidance 2020, which varied from mild (grade 2) to severe (grade 4) based on the patient’s symptoms. Additionally, our findings indicate that allergy to spirulina is not commonly reported or diagnosed. However, most of the described cases (four of five) regarding allergy to spirulina according to WAO Anaphylaxis Guidance 2020 were classified as anaphylaxis. Furthermore, it is noteworthy that spirulina also possesses antiallergic properties, as evidenced by research studies. Our article delves into both the allergic and antiallergic potential of spirulina. Full article
Show Figures

Figure 1

Full article ">Full article ">
15 pages, 808 KiB  
Review
Sex Differences in Cognitive Reflection: A Meta-Analysis
by Inmaculada Otero, Alexandra Martínez, Dámaris Cuadrado, Mario Lado, Silvia Moscoso and Jesús F. Salgado
J. Intell. 2024, 12(4), 39; https://doi.org/10.3390/jintelligence12040039 (registering DOI) - 29 Mar 2024
Abstract
The current study presents a meta-analytic review of the differences between men and women in cognitive reflection (CR). The study also explores whether the type of CR test (i.e., numerical tests and verbal tests) moderates the relationship between CR and sex. The results [...] Read more.
The current study presents a meta-analytic review of the differences between men and women in cognitive reflection (CR). The study also explores whether the type of CR test (i.e., numerical tests and verbal tests) moderates the relationship between CR and sex. The results showed that men score higher than women on CR, although the magnitude of these differences was small. We also found out that the type of CR test moderates the sex differences in CR, especially in the numerical tests. In addition, the results showed that the length of numerical tests (i.e., number of items) does not affect the differences between men and women in CR. Finally, the implications of these results are discussed, and future research is suggested. Full article
Show Figures

Figure 1

Full article ">
14 pages, 6061 KiB  
Article
Precipitation Variations in the Central Qilian Mountains since the 7th Century and Regional Differences: Evidence from Tree-Ring Data
by Taibang Zhang, Yong Zhang, Xuemei Shao and Xiuqi Fang
Forests 2024, 15(4), 624; https://doi.org/10.3390/f15040624 (registering DOI) - 29 Mar 2024
Abstract
The Qilian Mountains, located in northwest China and serving as a crucial water recharge area, have exhibited significant regional differences in precipitation patterns in recent decades. However, the limited temporal coverage of instrumental data has hindered a deep understanding of hydroclimate variations and [...] Read more.
The Qilian Mountains, located in northwest China and serving as a crucial water recharge area, have exhibited significant regional differences in precipitation patterns in recent decades. However, the limited temporal coverage of instrumental data has hindered a deep understanding of hydroclimate variations and regional differences. Further investigation into their long-term spatial and temporal precipitation characteristics is urgently needed. In this study, a new tree-ring-width chronology spanning 1743 years was established in the central Qilian Mountains using Qilian juniper (Juniperus przewalskii Kom.) samples. Significant correlations were found between the tree-ring indices and precipitation during both the growing and pre-growing seasons. Based on these correlations, annual precipitation from August of the previous year to July of the current year was reconstructed. The reconstruction model successfully explains 34.5% of the variation in precipitation during the calibration period. The analysis of the reconstructed series reveals notable interannual to multi-decadal dry–wet variability during the period from 614 AD to 2016 AD. The mid- to late-15th century emerges as the longest-lasting dry period, while the last decade stands out as the wettest. Comparative analysis with other precipitation reconstructions in the eastern and western Qilian Mountains reveals that regional drought events tend to be more pronounced and enduring. Low-frequency fluctuations on decadal to century scales show distinct wet and dry periods in the 12th–18th centuries in both the eastern and western parts of the Qilian Mountains, with weaker fluctuations in subsequent centuries. However, the central part of the Qilian Mountains exhibits opposite trends, possibly due to the complex interactions of multiple circulation systems. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
23 pages, 10577 KiB  
Article
Deformation and Strength of Unsaturated Loess—Hydraulic Coupling Effects under Loads
by Hao Chai, Xi’an Li, Biao Qin, Weiping Wang and Mani Axel
Water 2024, 16(7), 997; https://doi.org/10.3390/w16070997 (registering DOI) - 29 Mar 2024
Abstract
The volumetric change in unsaturated loess during loading causes serious damage to the foundation and structure, accompanied by changes in hydraulic conditions. Therefore, quantifying the change in the load effect of loess under hydraulic coupling is of great significance for revealing the mechanism [...] Read more.
The volumetric change in unsaturated loess during loading causes serious damage to the foundation and structure, accompanied by changes in hydraulic conditions. Therefore, quantifying the change in the load effect of loess under hydraulic coupling is of great significance for revealing the mechanism of hydraulic interaction. This study conducts isotropic compression and undrained shear tests on unsaturated compacted loess, simultaneously introducing the strength parameter η to enhance the Glasgow coupled model (GCM). The objective is to elucidate the hydraulic and mechanical coupling mechanism, where saturation increases under mechanical effects lead to strength degradation. The results show that saturation increases under mechanical effects improve the compressibility of the sample, and saturation has a direct impact on the stress–strain relationship. The increase in water content and confining pressure increases the trend of the critical state stress ratio M decreasing, and the strain softening trend increases. The compression of volume during shear tests increases the saturation, changes the hydraulic characteristics of loess, and affects the deformation and strength of loess. The modified GCM improves the applicability and prediction accuracy of unsaturated loess under the same initial state. The research results are of great significance for revealing the hydraulic and mechanical behavior of loess. Full article
(This article belongs to the Section Hydraulics and Hydrodynamics)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
13 pages, 1170 KiB  
Article
Parameterization of Biomechanical Variables through Inertial Measurement Units (IMUs) in Occasional Healthy Runners
by ?lvaro Pareja-Cano, José María Arjona, Brian Caulfield and Antonio Cuesta-Vargas
Sensors 2024, 24(7), 2191; https://doi.org/10.3390/s24072191 (registering DOI) - 29 Mar 2024
Abstract
Running is one of the most popular sports practiced today and biomechanical variables are fundamental to understanding it. The main objectives of this study are to describe kinetic, kinematic, and spatiotemporal variables measured using four inertial measurement units (IMUs) in runners during treadmill [...] Read more.
Running is one of the most popular sports practiced today and biomechanical variables are fundamental to understanding it. The main objectives of this study are to describe kinetic, kinematic, and spatiotemporal variables measured using four inertial measurement units (IMUs) in runners during treadmill running, investigate the relationships between these variables, and describe differences associated with different data sampling and averaging strategies. A total of 22 healthy recreational runners (M age = 28 ± 5.57 yrs) participated in treadmill measurements, running at their preferred speed (M = 10.1 ± 1.9 km/h) with a set-up of four IMUs placed on tibias and the lumbar area. Raw data was processed and analysed over selections spanning 30 s, 30 steps and 1 step. Very strong positive associations were obtained between the same family variables in all selections. The temporal variables were inversely associated with the step rate variable in the selection of 30 s and 30 steps of data. There were moderate associations between kinetic (forces) and kinematic (displacement) variables. There were no significant differences between the biomechanics variables in any selection. Our results suggest that a 4-IMU set-up, as presented in this study, is a viable approach for parameterization of the biomechanical variables in running, and also that there are no significant differences in the biomechanical variables studied independently, if we select data from 30 s, 30 steps or 1 step for processing and analysis. These results can assist in the methodological aspects of protocol design in future running research. Full article
(This article belongs to the Special Issue Movement Biomechanics Applications of Wearable Inertial Sensors)
Show Figures

Figure 1

Full article ">Full article ">
11 pages, 1189 KiB  
Article
Early Serum Markers for Immune Checkpoint Inhibitor Induced Hypophysitis in Melanoma Patients
by Fouad Mitri, Devayani Machiraju, Christina Naoum and Jessica C. Hassel
Cancers 2024, 16(7), 1340; https://doi.org/10.3390/cancers16071340 (registering DOI) - 29 Mar 2024
Abstract
Background: Immune checkpoint inhibitors (ICIs) have shown promising anti-tumor activities and are widely used for the treatment of advanced cancers. However, they may lead to immune-related adverse events (irAEs) and some of them, such as hypophysitis, can be life-threatening. Here, early diagnosis is [...] Read more.
Background: Immune checkpoint inhibitors (ICIs) have shown promising anti-tumor activities and are widely used for the treatment of advanced cancers. However, they may lead to immune-related adverse events (irAEs) and some of them, such as hypophysitis, can be life-threatening. Here, early diagnosis is critical. Methods: We retrospectively analyzed 40 melanoma patients who developed hypophysitis during ICI treatment with either ipilimumab and/or anti-PD1 therapy and compared them to 40 control patients who did not develop hypophysitis during the ICI treatment, matched for age, gender, type of immunotherapy, and stage. Clinical data and blood values such as LDH, CRP, TSH, T3, T4, and absolute immune cell counts were retrieved from the medical records. Patient characteristics, laboratory values, progression-free survival, and overall survival were compared between the two groups. Results: Patients with ir-hypophysitis had a median age of 59 years, and most of them were male. Clinically, frequent symptoms were fatigue, headache, dizziness, and gastrointestinal symptoms such as nausea or abdominal pain. The onset of ir-hypophysitis differed much between ipilimumab- (median 8 weeks) and anti-PD1 (median 40 weeks)-induced hypophysitis (p < 0.001). At baseline, besides a slightly increased CRP level (p = 0.06), no differences were observed in patients who later developed hypophysitis compared to the control. After treatment started, hypophysitis patients showed a constant and significant decline in T4 levels from the start of therapy until diagnosis (p < 0.05), independent of the ICI treatment regime. However, a decline in T3 and TSH was only noted in patients with ipilimumab-induced ir-hypophysitis. Furthermore, serum sodium levels declined rapidly at the diagnosis of hypophysitis (p < 0.001). In addition, there was a constant increase in the absolute counts of eosinophils and lymphocytes from baseline in hypophysitis patients (p < 0.05). Conclusion: Ir-hypophysitis reveals different clinical pictures and onset times depending on the ICI regime used. Whereas a drop in T4 levels was indicative of developing hypophysitis independent of the ICI regime, TSH levels only declined in patients under ipilimumab-based ICI regimes. To best monitor our patients, it is important to recognize these differences. Full article
(This article belongs to the Special Issue Oncology: State-of-the-Art Research in Germany)
Show Figures

Figure 1

Full article ">Full article ">Full article ">
19 pages, 15994 KiB  
Article
Geochemical Factors as a Tool for Distinguishing Geogenic from Anthropogenic Sources of Potentially Toxic Elements in the Soil
by Tomislav Brenko, Stanko Ru?i?i?, Niko Radoni?, Martina Puljko and Marko Cvetkovi?
Land 2024, 13(4), 434; https://doi.org/10.3390/land13040434 (registering DOI) - 29 Mar 2024
Abstract
Potentially toxic element (PTE) contamination of soils and their sources remains one of key global environmental concerns. Agricultural soil in Kalinovac, Podravina region, Croatia is the subject of this study. The main aims include determining the concentration and distribution of PTEs in the [...] Read more.
Potentially toxic element (PTE) contamination of soils and their sources remains one of key global environmental concerns. Agricultural soil in Kalinovac, Podravina region, Croatia is the subject of this study. The main aims include determining the concentration and distribution of PTEs in the soil, differentiation between possible geogenic and anthropogenic sources, and determining the correlation between the analysed PTEs and soil parameters. To achieve these objectives, geochemical analyses of the soil in the study area were carried out. Spatial distribution of the individual PTE contents, enrichment factors (EF), contamination factors (CF), and geoaccumulation index (Igeo) were created using GIS tools. In addition, statistical data processing was carried out, including the calculation of the correlation matrix, hierarchical cluster analysis (HCA), and factor analysis. The obtained results show that certain elements such as lead, chromium, copper, and cadmium were predominantly of anthropogenic origin in the study area, while others tended to have more geogenic origin. By applying different methods used in this study, it is possible to distinguish between geogenic and anthropogenic sources of PTEs in soils of this type. Full article
(This article belongs to the Section Soil-Sediment-Water Systems)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
15 pages, 6049 KiB  
Article
Analysis of the Impact of Hydraulic Gates on a Stabilized Tidal Inlet Structure: Mathematical Model and Data Measurements
by Alfonso Arrieta-Pastrana, Oscar E. Coronado-Hernández and Vicente S. Fuertes-Miquel
Hydrology 2024, 11(4), 46; https://doi.org/10.3390/hydrology11040046 (registering DOI) - 29 Mar 2024
Abstract
Tidal inlet structures are engineering projects with associated benefits related to flood control, water quality enhancement, and coastal protection. This study analyzes the performance of hydraulic gates on a stabilized inlet in estuarine systems by developing a simplified hydraulic model that considers inlet [...] Read more.
Tidal inlet structures are engineering projects with associated benefits related to flood control, water quality enhancement, and coastal protection. This study analyzes the performance of hydraulic gates on a stabilized inlet in estuarine systems by developing a simplified hydraulic model that considers inlet and outlet water levels. The proposed model was applied to the stabilized tidal inlet structure in Cartagena de Indias, Colombia. This model offers a practical tool for engineers and designers operating estuarine systems. The analysis focuses on the coastal lagoon of Ciénaga de la Virgen. The proposed model was successfully calibrated using two water sensors, with extreme input and outlet flow rates of approximately 260 m3/s and 110 m3/s, respectively. The average daily output volume in the system is 3,361,000 m3, while the average daily input volume is 3,200,000 m3. Consequently, the manipulation of the opening gates results in a decrease in the estuarine water level, potentially by as much as 25 cm, which local authorities can use to make decisions to reduce extreme water levels during flooding events. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
17 pages, 10416 KiB  
Article
Approach and Management of Pregnancies with Risk Identified by Non-Invasive Prenatal Testing
by Miruna Gug, Adrian Ra?iu, Nicoleta Andreescu, Simona Farca?, Sorina Laitin and Cristina Gug
J. Pers. Med. 2024, 14(4), 366; https://doi.org/10.3390/jpm14040366 (registering DOI) - 29 Mar 2024
Abstract
This study represents our second investigation into NIPT, involving a more extensive patient cohort with a specific emphasis on the high-risk group. The high-risk group was subsequently divided into two further groups to compare confirmed cases versus unconfirmed via direct methods. The methodology [...] Read more.
This study represents our second investigation into NIPT, involving a more extensive patient cohort with a specific emphasis on the high-risk group. The high-risk group was subsequently divided into two further groups to compare confirmed cases versus unconfirmed via direct methods. The methodology encompassed the analysis of 1400 consecutive cases from a single genetic center in western Romania, where NIPT was used to assess the risk of specific fetal chromosomal abnormalities. All high-risk cases underwent validation through direct analysis of fetal cells obtained via invasive methods, including chorionic villus sampling and amniocentesis. The confirmation process utilized QF-PCR, karyotyping, and SNP-Array methods customized to each case. Results: A high risk of aneuploidy at NIPT was identified in 36 out of 1400 (2.57%) cases and confirmed in 28 cases. The study also detected an increased risk for copy number variations (CNVs) in 1% of cases, confirmed in two instances involving one large microdeletion and one large microduplication. Trisomy 21 was the exclusive anomaly where NIPT confirmed all cases with identified risk. High-risk NIPT results which were not validated by invasive methods, were classified as false positives; parents in these cases determined to continue the pregnancy. In conclusion, NIPT can serve as a screening method for all pregnancies; however, in high-risk cases, an invasive confirmation test is strongly recommended. Full article
(This article belongs to the Special Issue Personalized Approaches to Prenatal Screening and Diagnosis)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
12 pages, 1158 KiB  
Article
Utilization of Ocrelizumab within Different Treatment Strategies for Multiple Sclerosis: A 5-Year Population-Based Study
by Marcello Moccia, Giuseppina Affinito, Giuseppina Marrazzo, Tiziana Ciarambino, Paolo Di Procolo, Licia Confalonieri, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Maria Triassi, Vincenzo Brescia Morra and Raffaele Palladino
Neurol. Int. 2024, 16(2), 394-405; https://doi.org/10.3390/neurolint16020029 (registering DOI) - 29 Mar 2024
Abstract
Background: We aim to provide up-to-date real-world evidence on the persistence, adherence, healthcare resource utilization, and costs of multiple sclerosis (MS) by comparing ocrelizumab to other disease-modifying treatments (DMTs) and within different DMT sequences. Methods: We included 3371 people with MS who first [...] Read more.
Background: We aim to provide up-to-date real-world evidence on the persistence, adherence, healthcare resource utilization, and costs of multiple sclerosis (MS) by comparing ocrelizumab to other disease-modifying treatments (DMTs) and within different DMT sequences. Methods: We included 3371 people with MS who first received or switched DMT prescriptions from January 2018 to December 2022; they were identified through hospital discharge records, drug prescriptions, and exemption codes from the Campania Region (South Italy). We calculated persistence (time from the first prescription to discontinuation or switching to another DMT), adherence (proportion of days covered (PDC)), DMT costs, and MS hospital admissions and related costs. Results: The most frequently prescribed DMT was dimethyl fumarate (n = 815; age 38.90 ± 11.91 years; 69.5% females), followed by ocrelizumab (n = 682; age 46.46 ± 11.29 years; 56.3%); 28.8% of the patients treated with ocrelizumab were naïve to DMTs. Using ocrelizumab as a statistical reference, the risk of discontinuation was higher for other highly active (HR = 6.32; 95%CI = 3.16, 12.63; p < 0.01) and low-/medium-efficacy DMTs (HR = 10.10; 95%CI = 5.10, 19.77; p < 0.01); adherence was lower for other highly active DMTs (Coeff = −0.07; 95%CI = −0.10, −0.04; p < 0.01) and low-/medium-efficacy DMTs (Coeff = −0.16; 95%CI = −0.19, −0.14; p < 0.01). monthly DMT costs were higher for other highly active DMTs (Coeff = 77.45; 95%CI = 29.36, 125.53; p < 0.01) but lower for low-/medium-efficacy DMTs (Coeff = −772.31; 95%CI = −816.95, −727.66; p < 0.01). The hospital admissions and related costs of MS were similar between ocrelizumab, other highly active DMTs, and other low-/medium-efficacy DMTs, and with ocrelizumab as the first-line DMT after other highly active DMTs and after low-/medium-efficacy DMTs, which was possibly due to the low number of observations. Conclusions: From 2018 to 2022, ocrelizumab was among the most frequently prescribed DMTs, with 28.8% prescriptions to incident MS patients, confirming its relevance in clinical practice. Ocrelizumab was associated with the highest persistence and adherence, pointing towards its favorable benefit–risk profile. The costs of ocrelizumab were lower than those of other highly active DMTs. Full article
Show Figures

Figure 1

Full article ">Full article ">
15 pages, 8960 KiB  
Article
A Signal-Processing-Based Simulation System for High-End Stereo Headsets
by Anna Zuccante, Alessandro Fiordelmondo, Pierluigi Bontempi and Sergio Canazza
Sensors 2024, 24(7), 2190; https://doi.org/10.3390/s24072190 (registering DOI) - 29 Mar 2024
Abstract
In recent years, headphones have become increasingly popular worldwide. There are numerous models on the market today, varying in technical characteristics and offering different listening experiences. This article presents an application for simulating the sound response of specific headphone models by physically wearing [...] Read more.
In recent years, headphones have become increasingly popular worldwide. There are numerous models on the market today, varying in technical characteristics and offering different listening experiences. This article presents an application for simulating the sound response of specific headphone models by physically wearing others. In the future, for example, this application could help to guide people who already own a pair of headphones during the decision-making process of purchasing a new headphone model. However, the potential fields of application are much broader. An in-depth study of digital signal processing was carried out with the implementation of a computational model. Prior to this, an analysis was performed on impulse response measurements of specific headphones, which allowed for a better understanding of the behavior of each set of headphones. Finally, an evaluation of the entire system was conducted through a listening test. The analysis of the results showed that the software works reasonably well in replicating the target headphones. We hope that this work will stimulate further efforts in the same direction. Full article
(This article belongs to the Special Issue Signal Processing and Machine Learning for Sensor Systems)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
19 pages, 4999 KiB  
Article
Energetic Features of H-Bonded and π-Stacked Assemblies in Pyrazole-Based Coordination Compounds of Mn(II) and Cu(II): Experimental and Theoretical Studies
by Mridul Boro, Trishnajyoti Baishya, Antonio Frontera, Miquel Barceló-Oliver and Manjit K. Bhattacharyya
Crystals 2024, 14(4), 318; https://doi.org/10.3390/cryst14040318 (registering DOI) - 29 Mar 2024
Abstract
Two new coordination compounds comprising Mn(II) and Cu(II) viz. [Mn(bz)2(Hdmpz)2(H2O)] (1) and [Cu(crot)2(Hdmpz)2] (2) (where, bz = benzoate; crot = crotonate; Hdmpz = 3, 5-dimethyl pyrazole) were synthesized and [...] Read more.
Two new coordination compounds comprising Mn(II) and Cu(II) viz. [Mn(bz)2(Hdmpz)2(H2O)] (1) and [Cu(crot)2(Hdmpz)2] (2) (where, bz = benzoate; crot = crotonate; Hdmpz = 3, 5-dimethyl pyrazole) were synthesized and characterized. The characterization involved a single crystal X-ray diffraction technique, FT-IR spectroscopy, electronic spectroscopy, TGA, and elemental analyses. Compounds 1 and 2 crystallize as mononuclear entities of Hdmpz with penta-coordinated Mn(II) and hexa-coordinated Cu(II), respectively. These complexes exhibit distorted trigonal bipyramidal and distorted octahedral geometries, respectively. A crystal structure analysis of compound 1 elucidates the existence of C–H⋯π and π-stacking interactions alongside O–H⋯O, N–H⋯O, and C–H⋯O H-bonding interactions contributing to the stabilization of the compound’s layered assembly. Similarly, in compound 2, the crystal structure stability is attributed to the presence of hydrogen bonding in conjugation with π-stacking interactions. We conducted theoretical investigations to analyze π⋯π, H-bonding, and antiparallel CH···π non-covalent interactions observed in compounds 1 and 2. DFT calculations were performed to find out the strength of these interactions energetically. Moreover, QTAIM and non-covalent interaction (NCI) plot index theoretical tools were employed to characterize them and evaluate the contribution of the H-bonds. Full article
(This article belongs to the Special Issue Coordination Complexes: Synthesis, Characterization and Application)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
20 pages, 22475 KiB  
Article
Assessing the Potential of Multi-Temporal Conditional Generative Adversarial Networks in SAR-to-Optical Image Translation for Early-Stage Crop Monitoring
by Geun-Ho Kwak and No-Wook Park
Remote Sens. 2024, 16(7), 1199; https://doi.org/10.3390/rs16071199 (registering DOI) - 29 Mar 2024
Abstract
The incomplete construction of optical image time series caused by cloud contamination is one of the major limitations facing the application of optical satellite images in crop monitoring. Thus, the construction of a complete optical image time series via image reconstruction of cloud-contaminated [...] Read more.
The incomplete construction of optical image time series caused by cloud contamination is one of the major limitations facing the application of optical satellite images in crop monitoring. Thus, the construction of a complete optical image time series via image reconstruction of cloud-contaminated regions is essential for thematic mapping in croplands. This study investigates the potential of multi-temporal conditional generative adversarial networks (MTcGANs) that use a single synthetic aperture radar (SAR) image acquired on a prediction date and a pair of SAR and optical images acquired on a reference date in the context of early-stage crop monitoring. MTcGAN has an advantage over conventional SAR-to-optical image translation methods as it allows input data of various compositions. As the prediction performance of MTcGAN depends on the input data composition, the variations in the prediction performance should be assessed for different input data combination cases. Such an assessment was performed through experiments using Sentinel-1 and -2 images acquired in the US Corn Belt. MTcGAN outperformed existing SAR-to-optical image translation methods, including Pix2Pix and supervised CycleGAN (S-CycleGAN), in cases representing various input compositions. In particular, MTcGAN was substantially superior when there was little change in crop vitality between the reference and prediction dates. For the SWIR1 band, the root mean square error of MTcGAN (0.021) for corn was significantly improved by 54.4% and 50.0% compared to Pix2Pix (0.046) and S-CycleGAN (0.042), respectively. Even when there were large changes in crop vitality, the prediction accuracy of MTcGAN was more than twice that of Pix2Pix and S-CycleGAN. Without considering the temporal intervals between input image acquisition dates, MTcGAN was found to be beneficial when crops were visually distinct in both SAR and optical images. These experimental results demonstrate the potential of MTcGAN in SAR-to-optical image translation for crop monitoring during the early growth stage and can serve as a guideline for selecting appropriate input images for MTcGAN. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
12 pages, 7649 KiB  
Article
Experimental Investigation on Pressure and Flame Surface Oscillation in a Dual-Cavity Scramjet Combustor
by Wenhao Liao, Yidan Chen and Ningfei Wang
Energies 2024, 17(7), 1639; https://doi.org/10.3390/en17071639 (registering DOI) - 29 Mar 2024
Abstract
Pressure and flame surface oscillations are common in supersonic combustion instability. Understanding the characteristics, generation, maintenance, and interaction mechanisms of these oscillations is crucial. An experimental setup with an alcohol heater was used to study injection positions and fuel quantities in a dual-cavity [...] Read more.
Pressure and flame surface oscillations are common in supersonic combustion instability. Understanding the characteristics, generation, maintenance, and interaction mechanisms of these oscillations is crucial. An experimental setup with an alcohol heater was used to study injection positions and fuel quantities in a dual-cavity scramjet combustion chamber. High-frequency pressure sensors and high-speed equipment were employed in this research. The most significant pressure oscillation occurred at a global equivalence ratio of 1.2 with a frequency of 300 Hz and an amplitude of 43%. Mean oscillation was not affected by changes in equivalence ratio. Increased amplitude was linked to stronger flow instability, indicating that flow instability induced by unstable heat release plays a significant role in supersonic combustion instability. Full article
(This article belongs to the Section I2: Energy and Combustion Science)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
12 pages, 3391 KiB  
Article
Development of Loop-Mediated Isothermal Amplification (LAMP) Assays for the Rapid Detection of Toxigenic Aspergillus flavus and A. carbonarius in Nuts
by Wanissa Mellikeche, Alessandra Ricelli, Giulia Casini, Marilita Gallo, Nuray Baser, Giancarlo Colelli and Anna Maria D’Onghia
Int. J. Mol. Sci. 2024, 25(7), 3809; https://doi.org/10.3390/ijms25073809 (registering DOI) - 29 Mar 2024
Abstract
Aspergillus species create major postharvest problems due to the food losses caused by their mere presence and the hazardous mycotoxins they produce, such as aflatoxin B1 (AFB1) and ochratoxin A (OTA). These mycotoxins are mainly produced by A. flavus and A. carbonarius, [...] Read more.
Aspergillus species create major postharvest problems due to the food losses caused by their mere presence and the hazardous mycotoxins they produce, such as aflatoxin B1 (AFB1) and ochratoxin A (OTA). These mycotoxins are mainly produced by A. flavus and A. carbonarius, respectively. In this study, we developed a rapid detection method for the two aforementioned species based on loop-mediated isothermal amplification (LAMP). The primers were designed to target genes belonging to the mycotoxin clusters pks and aflT for A. carbonarius and A. flavus, respectively. Result visualization was carried out in real time via the detection of fluorescent signals. The method developed showed high sensitivity and specificity, with detection limits of 0.3 and 0.03 pg/reaction of purified DNA of A. carbonarius and A. flavus, respectively. The assays were further implemented on inoculated nuts, including pistachios and almonds, after one-step crude DNA extraction. These tests revealed a detection level of 0.5 spore/g that shows the effectiveness of LAMP as a rapid method for detecting potentially toxigenic Aspergillus spp. directly in food. The validation of the assays included tests on a larger scale that further confirmed their sensitivity and specificity, as well as enabling the production of ready-to-use LAMP prototype kits. These kits are easy to use and aim to simplify the screening of food samples in order to monitor the presence of specific Aspergillus contaminations. Full article
(This article belongs to the Special Issue Molecular Interactions between Plants and Pests)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news