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65 pages, 11804 KiB  
Review
[18F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques
by Ma?lle Deleuziere, ?ric Benoist, Isabelle Quelven, Emmanuel Gras and Catherine Amiens
Molecules 2024, 29(7), 1537; https://doi.org/10.3390/molecules29071537 (registering DOI) - 29 Mar 2024
Abstract
A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient tools for the development of biomedical applications. [...] Read more.
A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient tools for the development of biomedical applications. However, bridging the gap between bench to bedside cannot be expected without a good knowledge of their behaviour in vivo, which can be obtained through non-invasive imaging techniques, such as positron emission tomography (PET). Their radiolabelling with [18F]-fluorine, a technique already well established and widely used routinely for PET imaging, with [18F]-FDG for example, and in preclinical investigation using [18F]-radiolabelled biological macromolecules, has, therefore, been developed. In this context, this review highlights the various nano-objects studied so far, the reasons behind their radiolabelling, and main in vitro and/or in vivo results obtained thereof. Then, the methods developed to introduce the radioelement are presented. Detailed indications on the chemical steps involved are provided, and the stability of the radiolabelling is discussed. Emphasis is then made on the techniques used to purify and analyse the radiolabelled nano-objects, a point that is rarely discussed despite its technical relevance and importance for accurate imaging. The pros and cons of the different methods developed are finally discussed from which future work can develop. Full article
(This article belongs to the Section Nanochemistry)
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28 pages, 1138 KiB  
Review
Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature
by Lampros G. Chrysavgis, Spyridon Kazanas, Konstantina Bafa, Sophia Rozani, Maria-Evangelia Koloutsou and Evangelos Cholongitas
Int. J. Mol. Sci. 2024, 25(7), 3832; https://doi.org/10.3390/ijms25073832 (registering DOI) - 29 Mar 2024
Abstract
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins that regulate postprandial glucose regulation, stimulating insulin secretion from pancreatic β-cells in response to food ingestion. Modified GLP-1 receptor agonists (GLP-1RAs) are being administered for the treatment of obesity and type 2 [...] Read more.
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins that regulate postprandial glucose regulation, stimulating insulin secretion from pancreatic β-cells in response to food ingestion. Modified GLP-1 receptor agonists (GLP-1RAs) are being administered for the treatment of obesity and type 2 diabetes mellitus (T2DM). Strongly related to those disorders, metabolic dysfunction-associated steatotic liver disease (MASLD), especially its aggressive form, defined as metabolic dysfunction-associated steatohepatitis (MASH), is a major healthcare burden associated with high morbidity and extrahepatic complications. GLP-1RAs have been explored in MASH patients with evident improvement in liver dysfunction enzymes, glycemic control, and weight loss. Importantly, the combination of GLP-1RAs with GIP and/or glucagon RAs may be even more effective via synergistic mechanisms in amelioration of metabolic, biochemical, and histological parameters of MASLD but also has a beneficial impact on MASLD-related complications. In this current review, we aim to provide an overview of incretins’ physiology, action, and signaling. Furthermore, we provide insight into the key pathophysiological mechanisms through which they impact MASLD aspects, as well as we analyze clinical data from human interventional studies. Finally, we discuss the current challenges and future perspectives pertinent to this growing area of research and clinical medicine. Full article
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12 pages, 2175 KiB  
Systematic Review
Visceral Adipose Tissue Depth as a Novel Predictor for Gestational Diabetes Mellitus: A Comprehensive Meta-Analysis and Systematic Review
by Weikun Li, Yi Jiang, Ling Feng and Jun Yu
Medicina 2024, 60(4), 557; https://doi.org/10.3390/medicina60040557 (registering DOI) - 29 Mar 2024
Abstract
Background and Objectives: The escalating prevalence of gestational diabetes mellitus (GDM) and the limitations associated with utilizing body mass index (BMI) as a predictive measure underscore the imperative need for identifying an optimal early pregnancy predictor. Such a predictor not only mitigates [...] Read more.
Background and Objectives: The escalating prevalence of gestational diabetes mellitus (GDM) and the limitations associated with utilizing body mass index (BMI) as a predictive measure underscore the imperative need for identifying an optimal early pregnancy predictor. Such a predictor not only mitigates the risk of GDM but also allows for timely implementation of interventions. Materials and Methods: This meta-analysis aimed to explore the association between visceral adipose tissue (VAT) depth and the risk of GDM. A thorough search of PubMed, Embase, and Web of Science databases was conducted up to 30 September 2023. The analysis employed a random-effects model to assess the relationship between VAT depth and the likelihood of GDM. Results: The inclusion criteria encompassed seven studies involving 1315 women, including 225 diagnosed with GDM. Significantly lower VAT depth was observed in the non-GDM group in comparison to the GDM group (Standardized Mean Difference [SMD]: 0.84; 95% Confidence Interval [CI]: 0.52–1.15; p < 0.001). Substantial statistical heterogeneity was noted among studies (I2 = 72.88%, p = 0.001). Through meticulous sensitivity and subgroup analyses, the source of heterogeneity was identified and thoroughly discussed. Subgroup analyses suggest that different GDM diagnostic criteria and VAT definitions all indicate higher VAT depth in GDM patients during early pregnancy. Conclusions: Our findings propose that, during the first trimester, GDM patients exhibit higher VAT depth compared to non-GDM women, highlighting VAT depth as a potential predictive factor for GDM in early pregnancy. This study contributes valuable evidence to the growing body of knowledge surrounding novel predictors for GDM, emphasizing the importance of early intervention strategies. Full article
(This article belongs to the Section Obstetrics and Gynecology)
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18 pages, 42038 KiB  
Article
LAEA: A 2D LiDAR-Assisted UAV Exploration Algorithm for Unknown Environments
by Xiaolei Hou, Zheng Pan, Li Lu, Yuhang Wu, Jinwen Hu, Yang Lyu and Chunhui Zhao
Drones 2024, 8(4), 128; https://doi.org/10.3390/drones8040128 (registering DOI) - 29 Mar 2024
Abstract
In UAV autonomous exploration, large frontier clusters are commonly associated with high information gain and are visited first. In contrast, small and isolated frontier clusters with fewer frontiers are associated with smaller information gain and are thus explored with low priority. However, these [...] Read more.
In UAV autonomous exploration, large frontier clusters are commonly associated with high information gain and are visited first. In contrast, small and isolated frontier clusters with fewer frontiers are associated with smaller information gain and are thus explored with low priority. However, these small and isolated frontier clusters are often in close proximity to UAVs and surrounded by explored areas, which could result in back-and-forth flights that lower exploration efficiency. This paper proposes LAEA, a LiDAR-assisted and depth camera-dominated UAV exploration algorithm that aims to improve UAV autonomous exploration efficiency. A hybrid map is obtained that characterizes rich environmental profile information in real time, enabling us to detect small and isolated frontier clusters that can lead to repeated visits to explored areas. An environmental information gain optimization strategy is incorporated such that frontier clusters with larger unexplored areas behind them, as well as small and isolated frontier clusters close to the UAV, are assigned higher weights to prioritize their visit order. An optimized flight trajectory is generated to cover unexplored frontier clusters in the immediate vicinity of the UAV while flying to the next target. A comprehensive comparison between the proposed algorithm and state-of-the-art algorithms was conducted via a simulation study, which showed that our algorithm exhibits superior exploration efficiency in various environments. Experiments were also carried out to verify the feasibility of the proposed approach in real-world scenarios. Full article
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14 pages, 3956 KiB  
Article
Quality Evaluation and Identification of Phyllanthi fructus (Yuganzi) Based on the Spectrum-Effect Relationship
by Weiwei Zhou, Bencheng Wu, Ling Liu, Jun Li, Dongdong Shi and Xiumei Li
Separations 2024, 11(4), 104; https://doi.org/10.3390/separations11040104 (registering DOI) - 29 Mar 2024
Abstract
To establish a quality evaluation and identification method for Phyllanthi fructus (Yuganzi), the spectrum-effect relationship was explored. A high-performance liquid chromatography (HPLC) fingerprint was established using ultraviolet spectrophotometry, and the in vitro antioxidant activity was determined using a total antioxidant capacity assay kit. [...] Read more.
To establish a quality evaluation and identification method for Phyllanthi fructus (Yuganzi), the spectrum-effect relationship was explored. A high-performance liquid chromatography (HPLC) fingerprint was established using ultraviolet spectrophotometry, and the in vitro antioxidant activity was determined using a total antioxidant capacity assay kit. Similarity analysis, hierarchical cluster analysis (HCA), and partial least squares regression (PLSR) were performed to establish the spectrum-effect relationships. Thirteen batches of Yuganzi were collected for testing. The results revealed that the optimal chromatographic conditions for the HPLC fingerprint were as follows: the mobile phase consisted of 0.1% phosphoric acid solution (A) and acetonitrile (B), the detection wavelength was 214 nm, the column temperature was 30 °C, and the flow rate was 0.8 mL/min. Among the batches of samples, the similarity values of 10 samples (S1–S10) from Yunnan were larger than 0.995; the similarity values of 3 samples (S11–S13) from India, Gaoligong Mountain, and Fujian were less than or equal to 0.986. Furthermore, nineteen characteristic peaks of Yuganzi were calibrated using fingerprint evaluation software. The study on the spectrum-effect relationship further revealed that compounds corresponding to peaks 5 and 8 were potentially key ingredients for the quality evaluation and identification of Yuganzi, closely related to the stable antioxidant activities of Yuganzi. The spectrum-effect relationship is an agile and efficient approach that can ensure the intra-assay stability of Yuganzi from same region and identify Yuganzi from different regions. Compounds with antioxidant activity can be identified as quality markers for Yuganzi. Full article
(This article belongs to the Section Analysis of Natural Products and Pharmaceuticals)
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26 pages, 4888 KiB  
Article
Designing a Reverse Logistics Network for End-of-Life Vehicles in an Uncertain Environment
by Meiling He, Qipeng Li, Tianhe Lin, Jiangyang Fan, Xiaohui Wu and Xun Han
World Electr. Veh. J. 2024, 15(4), 140; https://doi.org/10.3390/wevj15040140 (registering DOI) - 29 Mar 2024
Abstract
The strategic development of reverse logistics networks is crucial for addressing the common challenge of low recovery rates for end-of-life vehicles (ELVs) in China. To minimize the total cost of the reverse logistics network for ELVs, this paper proposes a mixed-integer linear programming [...] Read more.
The strategic development of reverse logistics networks is crucial for addressing the common challenge of low recovery rates for end-of-life vehicles (ELVs) in China. To minimize the total cost of the reverse logistics network for ELVs, this paper proposes a mixed-integer linear programming (MILP) model. The model considers the recycling volume of different vehicle types, facility processing capacity, and the proportions of parts and materials. Building on this foundation, a fuzzy mixed-integer nonlinear programming (FMINLP) model is developed to account for the inherent uncertainty associated with recycling volumes and facility processing capacities. The model was solved using Lingo, and its effectiveness was validated using Jiangsu Province of China as a case study, followed by a sensitivity analysis. The results indicate that dismantling and machining centers incur the highest processing costs. Variations in recycling volume and facility handling capacity significantly impact total costs and site selection, with the former having a more pronounced effect. Increasing facility processing capacity effectively increases the recovery rate. Moreover, a higher confidence level corresponds to higher total costs and a greater demand for facilities. Full article
(This article belongs to the Special Issue Advanced Vehicle System Dynamics and Control)
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15 pages, 698 KiB  
Article
Effects of Manual Therapy Plus Pain Neuroscience Education with Integrated Motivational Interviewing in Individuals with Chronic Non-Specific Low Back Pain: A Randomized Clinical Trial Study
by Konstantinos Kasimis, Thomas Apostolou, Ilias Kallistratos, Dimitrios Lytras and Paris Iakovidis
Medicina 2024, 60(4), 556; https://doi.org/10.3390/medicina60040556 (registering DOI) - 29 Mar 2024
Abstract
Background and Objectives: Chronic non-specific low back pain (CNLBP) persists beyond 12 weeks. Manual therapy recommended for CNLBP demonstrates short-term efficacy. Pain Neuroscience Education (PNE) teaches patients to modify pain perception through explanations, metaphors, and examples, targeting brain re-education. Motivational Interviewing (MI) [...] Read more.
Background and Objectives: Chronic non-specific low back pain (CNLBP) persists beyond 12 weeks. Manual therapy recommended for CNLBP demonstrates short-term efficacy. Pain Neuroscience Education (PNE) teaches patients to modify pain perception through explanations, metaphors, and examples, targeting brain re-education. Motivational Interviewing (MI) enhances motivation for behavioral change, steering patients away from ambivalence and uncertainty. These approaches collectively address the multifaceted nature of CNLBP for effective management. The aim of this study was to investigate a manual therapy intervention combined with PNE with MI on pain, pressure pain threshold (PPT), disability, kinesiophobia, catastrophizing, and low back functional ability in individuals experiencing CNLBP. Materials and Methods: Sixty adults with CNLBP were randomly divided into three equal groups (each n = 20). The first group received manual therapy and PNE with integrated MI (combined therapy group), the second group underwent only manual therapy (manual therapy group), and the third group followed a general exercise program at home (control group). Pain in the last 24 h was assessed using the Numeric Pain Rating Scale (NPRS), functional ability with the Roland–Morris Disability Questionnaire (RMDQ), PPT in the lumbar region through pressure algometry, kinesiophobia with the Tampa Scale for Kinesiophobia (TSK), catastrophizing with the Pain Catastrophizing Scale (PCS), and performance using the Back Performance Scale (BPS) at baseline, in the fourth week, and six months post-intervention. Results: Statistically significant differences between the intervention groups and the control group were found in both the fourth-week measurement and the six-month follow-up, as evident in the NPRS and RMDQ scores, as well as in the total values of tested PPTs (p < 0.05). Differences were also observed between the two intervention groups, with a statistically greater improvement in the combined therapy group at both time points (fourth week and six-month follow-up) (p < 0.05). Regarding the TSK and PCS scores in the fourth week, statistically significant differences were observed between the two intervention groups compared to the control group, as well as between the two intervention groups (p < 0.05). However, in the six-month follow-up, statistically significant differences were found only between the combined therapy group and the other two groups, with the combined therapy group showing significant improvements (p < 0.05). In relation to BPS, both intervention groups exhibited statistically significant differences compared to the control group in the fourth week, without any significant differences between the two intervention groups. However, in the six-month follow-up, significant differences were noted between the combined therapy group and the other two groups (p < 0.05), with combined therapy demonstrating greater improvement. Conclusions: The addition of PNE with integrated MI enhanced the positive effects of a manual therapy intervention in all outcome measures. The combination of manual therapy plus PNE with integrated MI appeared to provide greater improvements compared to the isolated application of manual therapy, and these improvements also lasted longer. These short- and long-term positive effects are likely attributed to the combination of PNE with integrated MI, which contributed to increasing the effectiveness of the treatment. Further studies are required to investigate the optimum dosage of manual therapy and PNE with integrated MI in individuals with CNLBP. Full article
(This article belongs to the Section Neurology)
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14 pages, 2348 KiB  
Article
Jitter Measurements of 1 cm2 LGADs for Space Experiments
by Ashish Bisht, Leo Cavazzini, Matteo Centis Vignali, Fabiola Caso, Omar Hammad Ali, Francesco Ficorella, Maurizio Boscardin and Giovanni Paternoster
Instruments 2024, 8(2), 27; https://doi.org/10.3390/instruments8020027 (registering DOI) - 29 Mar 2024
Abstract
This work explores the possibility of using Low Gain Avalanche Diodes (LGADs) for tracker-based experiments studying Charged Cosmic Rays (CCRs) in space. While conventional silicon microstrip sensors provide only spatial information about the charged particle passing through the tracker, LGADs have the potential [...] Read more.
This work explores the possibility of using Low Gain Avalanche Diodes (LGADs) for tracker-based experiments studying Charged Cosmic Rays (CCRs) in space. While conventional silicon microstrip sensors provide only spatial information about the charged particle passing through the tracker, LGADs have the potential to provide additional timing information with a resolution in the order of tens of picoseconds. For the first time, it has been demonstrated that an LGAD with an active area of approximately 1 cm2 can achieve a jitter of less than 40 ps. A comparison of design and gain layers is carried out to understand which provides the best time resolution. For this purpose, laboratory measurements of sensors’ electrical properties and gain using LED and an Infrared laser, as well as their jitter, were performed. Full article
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11 pages, 594 KiB  
Article
Disentangling Gender and Relative Age Effects in Women’s and Girls’ Rugby Union
by Adam L. Kelly, Diogo Coutinho, John M. Radnor, Kate Burke, Donald Barrell, Daniel Jackson and Paolo R. Brustio
J. Funct. Morphol. Kinesiol. 2024, 9(2), 61; https://doi.org/10.3390/jfmk9020061 (registering DOI) - 29 Mar 2024
Abstract
Relative age effects (RAEs) within sports refer to the overrepresentation of athletes born earlier in the selection year and the underrepresentation of those born later in the selection year. Research examining RAEs in women’s and girls’ rugby union remains limited in comparison to [...] Read more.
Relative age effects (RAEs) within sports refer to the overrepresentation of athletes born earlier in the selection year and the underrepresentation of those born later in the selection year. Research examining RAEs in women’s and girls’ rugby union remains limited in comparison to the male literature, whilst the impacts of RAEs on the youth–senior transition are yet to be explored in a female sport context. As such, the purpose of this study was to examine RAEs during entry into the women’s and girls’ premiership and international rugby union pathways in England, as well as to compare them to their respective senior cohort (n = 1367): (a) U18 England Rugby Centre of Excellence Player (n = 325) vs. Senior Premiership Player (n = 868), and (b) U18 England Player (n = 49) vs. Senior England Player (n = 125). Chi-square (χ2) analyses compared birth quarter (BQ) distributions against expected distributions. The findings revealed no significant difference in BQ distributions at either youth or senior levels, as well as no significant differences in the BQ distributions of those who were likely to transition from youth to senior levels (all p > 0.05). Importantly, though, descriptive statistics showed a skewed birthdate distribution in both U18 England Rugby Centre of Excellence Player (BQ1 = 30% vs. BQ4 = 20%) and U18 England Player cohorts (BQ1 = 33% vs. BQ4 = 18%). We highlight the gender-specific mechanisms that potentially explain the variations between male and female RAEs in rugby union, including developmental differences, sport popularity, and sociocultural norms. We also warn against a ‘copy and paste’ template from the male provision to ensure the recent growth of female rugby union does not fall victim to the same RAEs in the future. Full article
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11 pages, 221 KiB  
Article
Visiting with Elders—Aging, Caregiving, and Planning for Future Generations of American Indians and Alaska Natives
by Cole Allick and Marija Bogic
Genealogy 2024, 8(2), 36; https://doi.org/10.3390/genealogy8020036 (registering DOI) - 29 Mar 2024
Abstract
(1) Background: To address the importance of engaging American Indian and Alaska Native Elders in a dialogue about healthy aging and fill the gap in the scholarly literature on this topic. (2) Methods: This study conducted a listening session with Elders who attended [...] Read more.
(1) Background: To address the importance of engaging American Indian and Alaska Native Elders in a dialogue about healthy aging and fill the gap in the scholarly literature on this topic. (2) Methods: This study conducted a listening session with Elders who attended the 2021 National Indian Council on Aging (NICOA) Annual Conference in Reno, Nevada. The listening session was audio-recorded and transcribed for thematic analysis by two analysts. (3) Results: Important insights regarding American Indian and Alaska Native Elders’ perspectives on planning for future care and aging-related diseases, such as Alzheimer’s disease. (4) Conclusions: This study is one of the first to engage American Indian and Alaska Native Elders in a conversation about health aging. Calls for intergenerational solidarity, protection of Elders, education, and relationality were found to be important themes. Full article
(This article belongs to the Special Issue The Health and Wellbeing of Indigenous Peoples)
16 pages, 5943 KiB  
Article
Mycorrhizal Symbiosis Enhances P Uptake and Indole-3-Acetic Acid Accumulation to Improve Root Morphology in Different Citrus Genotypes
by Chunyan Liu, Xiaoniu Guo, Fengjun Dai and Qiangsheng Wu
Horticulturae 2024, 10(4), 339; https://doi.org/10.3390/horticulturae10040339 (registering DOI) - 29 Mar 2024
Abstract
Arbuscular mycorrhizal fungi (AMF) are known to enhance plant growth via stimulation of root system development. However, the extent of their effects and underlying mechanisms across different citrus genotypes remain to be fully elucidated. This study investigates the impact of Funneliformis mosseae ( [...] Read more.
Arbuscular mycorrhizal fungi (AMF) are known to enhance plant growth via stimulation of root system development. However, the extent of their effects and underlying mechanisms across different citrus genotypes remain to be fully elucidated. This study investigates the impact of Funneliformis mosseae (F. mosseae) inoculation on plant growth performance, root morphology, phosphorus (P), and indole-3-acetic acid (IAA) concentrations, as well as the expression of related synthesis and transporter genes in three citrus genotypes: red tangerine (Citrus tangerine ex. Tanaka), kumquat (Fortunella margarita L. Swingle), and fragrant citrus (Citrus junos Sieb. ex. Tanaka). Following 12 weeks of inoculation, significant improvements were observed in plant height, shoot and root biomass, total root length, average root diameter, second-order lateral root development, root hair density, and root hair length across all genotypes. Additionally, F. mosseae inoculation significantly increased root P and IAA concentrations in the three citrus genotypes. Notably, phosphatase activity was enhanced in F. margarita but reduced in C. tangerine and C. junos following inoculation. Gene expression analysis revealed a universal upregulation of the P transporter gene PT5, whereas expressions of the auxin synthesis gene YUC2, transporter gene LAX2, and phosphatase gene PAP1 were commonly downregulated. Specific to genotypes, expressions of YUC5, LAX5, PIN2, PIN3, PIN6, and expansin genes EXPA2 and EXPA4 were significantly upregulated in C. tangerine but downregulated in F. margarita and C. junos. Principal component analysis and correlation assessments highlighted a strong positive association between P concentration, P and auxin synthesis, and transporter gene expressions with most root morphology traits, except for root average diameter. Conversely, IAA content and phosphatase activities were negatively correlated with these root traits. These findings suggest that F. mosseae colonization notably enhances plant growth and root system architecture in citrus genotypes via modifications in P transport and IAA accumulation, indicating a complex interplay between mycorrhizal symbiosis and host plant physiology. Full article
(This article belongs to the Special Issue Citrus Plant Growth and Fruit Quality)
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16 pages, 2999 KiB  
Article
A Study of Thermal Runaway Mechanisms in Lithium-Ion Batteries and Predictive Numerical Modeling Techniques
by Alexander Sorensen, Vivek Utgikar and Jeffrey Belt
Batteries 2024, 10(4), 116; https://doi.org/10.3390/batteries10040116 (registering DOI) - 29 Mar 2024
Abstract
While thermal runaway characterization and prediction is an important aspect of lithium-ion battery engineering and development, it is a requirement to ensure that a battery system can be safe under normal operations and during failure events. This study investigated the current existing literature [...] Read more.
While thermal runaway characterization and prediction is an important aspect of lithium-ion battery engineering and development, it is a requirement to ensure that a battery system can be safe under normal operations and during failure events. This study investigated the current existing literature regarding lithium-ion battery thermal runaway characterization and predictive modeling methods. A thermal model for thermal runaway prediction was adapted from the literature and is presented in this paper along with a comparison of empirical data and predicted data using the model. Empirical data were collected from a Samsung 30Q 18650 cylindrical cell and from a large 20 Ah pouch cell format using accelerated rate calorimetry. The predictive model was executed in a macro-enabled Microsoft Excel workbook for simplicity and accessibility for the public. The primary purpose of using more primitive modeling software was to provide an accurate model that was generally accessible without the purchase of or training in a specific modeling software package. The modes of heat transfer during the thermal runaway event were studied and are reported in this work, along with insights on thermal management during a thermal runaway failure event. Full article
(This article belongs to the Collection Recent Advances in Battery Management Systems)
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30 pages, 7828 KiB  
Article
Ostrom’s Razor: Using Bitcoin to Cut Fraud in Hollywood Accounting
by Ted Rivera and Dave Foderick
J. Risk Financial Manag. 2024, 17(4), 139; https://doi.org/10.3390/jrfm17040139 (registering DOI) - 29 Mar 2024
Abstract
The accounting principles prevalent in Hollywood are seemingly crafted to mislead creators and investors. Film studios and streaming platforms have been found to use complex strategies to annually divert millions in net profits. Many contracts include audit clauses, but the cost of auditing [...] Read more.
The accounting principles prevalent in Hollywood are seemingly crafted to mislead creators and investors. Film studios and streaming platforms have been found to use complex strategies to annually divert millions in net profits. Many contracts include audit clauses, but the cost of auditing a billion-dollar system is prohibitive for most creatives with “net profit” deals. However, a resourceful minority have recovered billions in profits and damages. We suggest using Bitcoin’s transparent, immutable ledger to eliminate fraudulent accounting and build trust among profit-seeking filmmakers willing to trade maximum income for maximum profit per share. This trust can be spread globally utilizing the Bitcoin network as a transparent and immutable triple-entry accounting system. Our research shows that distributing this decentralized trust is achievable by configuring an ecosystem of existing Bitcoin wallets, applications, and recorded contracts to create a universal source of truth for all parties assisting in the creation of valuable content in the form of movies. This network can form the foundation on which to build a legal blockchain infrastructure that can eventually facilitate the sale of tokenized securities, discretely disseminate recorded financial data, and transparently distribute revenue to a collective of filmmakers indefinitely. Full article
(This article belongs to the Special Issue Triple Entry Accounting)
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16 pages, 5342 KiB  
Article
Optimizing ‘Xinomavro’ (Vitis vinifera L.) Performance by Post-Bloom Basal Leaf Removal Applications
by Serafeim Theocharis, Dimitrios Taskos, Theodoros Gkrimpizis, Kleopatra-Eleni Nikolaou, Dimitrios-Evangelos Miliordos and Stefanos Koundouras
Horticulturae 2024, 10(4), 340; https://doi.org/10.3390/horticulturae10040340 (registering DOI) - 29 Mar 2024
Abstract
A three-year study was conducted to investigate the effects of two timings—at berry set and at veraison—of post-bloom leaf removal (LR) applications from the basal sections of the shoot on the growth, yield, and berry composition of Vitis vinifera L. cv. Xinomavro, the [...] Read more.
A three-year study was conducted to investigate the effects of two timings—at berry set and at veraison—of post-bloom leaf removal (LR) applications from the basal sections of the shoot on the growth, yield, and berry composition of Vitis vinifera L. cv. Xinomavro, the major red winegrape of North Greece. LR at berry set drastically reduced yield by affecting all its components while increasing the ratio of secondary foliage per total leaf area. LR at veraison had a milder effect on growth and yield. Both treatments increased sugar and phenolic compound levels in berries, while early LR increased the contribution of more stable forms of anthocyanins. Additionally, early LR increased the skin-to-pulp ratio, suggesting that it could be an effective viticultural technique for more concentrated red wines. Overall, both LR timings improved most of the berry attributes compared to the non-treated vines; however, the earlier application can be recommended when aiming at the production of deep-colored and richly flavored wines. Full article
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20 pages, 3875 KiB  
Article
Insight into CMC-PVA-fHNTs Nanocomposite Hydrogel as an Advance Carrier for Cefadroxil Monohydrate: Fabrication and Characterization/Angiogenic Potential Analysis
by Saba Zia, Shahzad Maqsood Khan, Muhammad Taqi Zahid Butt and Nafisa Gull
Gels 2024, 10(4), 235; https://doi.org/10.3390/gels10040235 (registering DOI) - 29 Mar 2024
Abstract
Controlled drug delivery is a key strategy aimed at reducing both the frequency of therapeutic dosages and potential systemic side effects, particularly in the case of high drug concentrations. The nanocomposite hydrogel systems presented in this study were synthesized by combining carboxymethyl cellulose, [...] Read more.
Controlled drug delivery is a key strategy aimed at reducing both the frequency of therapeutic dosages and potential systemic side effects, particularly in the case of high drug concentrations. The nanocomposite hydrogel systems presented in this study were synthesized by combining carboxymethyl cellulose, polyvinyl alcohol, and (3-aminopropyl)triethoxysilane-functionalized halloysite nanotubes (fHNTs). This hydrogel system is a potential candidate for the controlled release of cefadroxil monohydrate. These hydrogels are analyzed by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and rheological measurements. Additionally, swelling properties, porosity, hydrophilicity, drug release, and in vitro and in vivo analyses were also evaluated. The observed trends in swelling and drug release demonstrated that the outcomes are dependent on the presence of fHNTs in the hydrogel matrix. Notably, fHNTs-loaded hydrogels displayed sustained drug release patterns. This innovative approach eliminates the need for traditional encapsulation and presents promising and translatable strategies for achieving more effective drug release. Full article
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17 pages, 2630 KiB  
Article
Development and Characterization of a Hand Rub Gel Produced with Artisan Alcohol (Puntas), Silver Nanoparticles, and Saponins from Quinoa
by Oscar Analuiza, Belen Paredes, Alejandra Lascano, Santiago Bonilla and José-Luis Martínez-Guitarte
Gels 2024, 10(4), 234; https://doi.org/10.3390/gels10040234 (registering DOI) - 29 Mar 2024
Abstract
The emergence of the global pandemic (COVID-19) has directed global attention towards the importance of hygiene as the primary defense against various infections. In this sense, one of the frequent recommendations of the World Health Organization (WHO) is regular hand washing and the [...] Read more.
The emergence of the global pandemic (COVID-19) has directed global attention towards the importance of hygiene as the primary defense against various infections. In this sense, one of the frequent recommendations of the World Health Organization (WHO) is regular hand washing and the use of alcohol-based hand sanitizers. Ethanol is the most widely used alcohol due to its effectiveness in eliminating pathogens, ease of use, and widespread production. However, artisanal alcohol, generally used as a spirit drink, could be a viable alternative for developing sanitizing gels. In this study, the use of alcohol “Puntas”, silver nanoparticles, and saponins from quinoa was evaluated to produce hand sanitizer gels. The rheological, physicochemical, and antimicrobial properties were evaluated. In the previous assays, the formulations were adjusted to be similar in visual viscosity to the control gel. A clear decrease in the apparent viscosity was observed with increasing shear rate, and an inversely proportional relationship was observed with the amount of ethyl alcohol used in the formulations. The flow behavior index (n) values reflected a pseudoplastic behavior. Oscillatory dynamic tests were performed to analyze the viscoelastic behavior of gels. A decrease in storage modulus (G′) and an increase in loss modulus (G″) as a function of the angular velocity (ω) was observed. The evaluation of pH showed that the gels complied with the requirements to be in contact with the skin of the people, and the textural parameters showed that the control gel was the hardest. The use of artisan alcohol could be an excellent alternative to produce sanitizer gel and contribute to the requirements of the population. Full article
(This article belongs to the Special Issue Designing Gels for Antibacterial and Antiviral Agents)
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17 pages, 1202 KiB  
Article
Boosting Tomato Resilience in Tanzania: Grafting to Combat Bacterial Wilt and Abiotic Stress
by Shem Elias Msabila, Thibault Nordey, Zablon Ernest, Nickson Mlowe, Ravishankar Manickam, Srinivasan Ramasamy and Jo?l Huat
Horticulturae 2024, 10(4), 338; https://doi.org/10.3390/horticulturae10040338 (registering DOI) - 29 Mar 2024
Abstract
The grafting technique has successfully mitigated crop losses from diseases and stress in vegetable production; however, vegetable grafting in Tanzania is very limited. Field and greenhouse experiments conducted in Tanzania’s mainland and islands compared the response of tomato determinate cv. ‘Tanya’ to production [...] Read more.
The grafting technique has successfully mitigated crop losses from diseases and stress in vegetable production; however, vegetable grafting in Tanzania is very limited. Field and greenhouse experiments conducted in Tanzania’s mainland and islands compared the response of tomato determinate cv. ‘Tanya’ to production challenges when ungrafted and grafted onto five tomato rootstocks (‘Hawaii 7796’, ‘Tengeru 1997’, ‘Tengeru 2010’, ‘R3034’, and ‘Shelter’), one eggplant variety (‘EG 203’), and one wild Solanum species (Solanum elaeagnifolium). The visual symptoms of bacterial wilt varied significantly with location and season, ranging from 8 to 100%, attributed to varying bacterial wilt pressures and strains of Ralstonia solanacearum isolated (Phylotype I sequevars 17, 18, and 31). ‘EG203’ and ‘Hawaii 7796’ emerged as the most effective rootstocks, reducing wilting by 49.8 and 51.0% and improving yield by 57.2% and 27.7% on average across experiments conducted in three locations (Moshi, Pemba, and Unguja) over two seasons. Combining reduced water supply with grafting resulted in an average reduction in wilting of 76%, while also boosting yields by an average of 3.6 times in experiments conducted in Arusha over two seasons. Grafting onto ‘Hawaii 7796’ and ‘Shelter’ significantly improved ‘Tanya’ yields by 38.3% and 41.6% on average over two seasons, only under standard nutrient application rates. While certain rootstocks improved crop performance, yields across various sites and seasons were significantly hampered by pest pressure. These findings support grafting’s potential to mitigate damage from common stresses, emphasizing the need for further research to identify suitable rootstocks for optimizing returns on investments in grafted plants in Tanzania. Full article
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15 pages, 2558 KiB  
Article
Preparation, Purification, Characterization and Antioxidant Activity of Rice Bran Fermentation Broth with Hypsizigus marmoreus
by Yanping Chi, Lining Kang, Xiangying Liu, Hongrui Sun, Yue Meng, Jialin Zhang, You Kang and Yonggang Dai
Fermentation 2024, 10(4), 188; https://doi.org/10.3390/fermentation10040188 (registering DOI) - 29 Mar 2024
Abstract
The main purpose of this study was to investigate the composition, characterization and antioxidant activity of rice bran fermentation broth, and provide a new way for high-value utilization of rice bran. Firstly, we fermented rice bran with Hypsizigus marmoreus and purified fermentation broth [...] Read more.
The main purpose of this study was to investigate the composition, characterization and antioxidant activity of rice bran fermentation broth, and provide a new way for high-value utilization of rice bran. Firstly, we fermented rice bran with Hypsizigus marmoreus and purified fermentation broth with macroporous resins. We took feruloyl oligosaccharides (FOs) concentration as the measure index, and the results showed that the maximum concentration of FOs was 0.72 mmol/L on the 6th day of rice bran fermentation. We took D101 macroporous resin as adsorption resin for rice bran fermentation broth, and the result showed that FOs concentration reached 2.38 mmol/L with the optimal purification process at pH 4.5, temperature 29 °C, ethanol concentration 55%, sample flow rate 1.5 mL/min, sample concentration 1.7 mL/min and elution flow rate 2.0 mmol/L. Secondly, the characters of rice bran fermentation broth were identified by high-performance liquid chromatography (HPLC) and Fourier-transform infrared spectroscopy (FTIR). These methods showed the presence of ferulic acid (FA), arabinose, xylose and glucose in rice bran fermentation broth. Finally, the in vitro antioxidant activities of rice bran fermentation broth were tested and the result showed that fermentation broth had good antioxidant activities and significantly improved after purification. Full article
(This article belongs to the Special Issue Food Wastes: Feedstock for Value-Added Products: 5th Edition)
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11 pages, 3299 KiB  
Article
Applying Self-Supervised Learning to Image Quality Assessment in Chest CT Imaging
by Eléonore Pouget and Véronique Dedieu
Bioengineering 2024, 11(4), 335; https://doi.org/10.3390/bioengineering11040335 (registering DOI) - 29 Mar 2024
Abstract
Many new reconstruction techniques have been deployed to allow low-dose CT examinations. Such reconstruction techniques exhibit nonlinear properties, which strengthen the need for a task-based measure of image quality. The Hotelling observer (HO) is the optimal linear observer and provides a lower bound [...] Read more.
Many new reconstruction techniques have been deployed to allow low-dose CT examinations. Such reconstruction techniques exhibit nonlinear properties, which strengthen the need for a task-based measure of image quality. The Hotelling observer (HO) is the optimal linear observer and provides a lower bound of the Bayesian ideal observer detection performance. However, its computational complexity impedes its widespread practical usage. To address this issue, we proposed a self-supervised learning (SSL)-based model observer to provide accurate estimates of HO performance in very low-dose chest CT images. Our approach involved a two-stage model combining a convolutional denoising auto-encoder (CDAE) for feature extraction and dimensionality reduction and a support vector machine for classification. To evaluate this approach, we conducted signal detection tasks employing chest CT images with different noise structures generated by computer-based simulations. We compared this approach with two supervised learning-based methods: a single-layer neural network (SLNN) and a convolutional neural network (CNN). The results showed that the CDAE-based model was able to achieve similar detection performance to the HO. In addition, it outperformed both SLNN and CNN when a reduced number of training images was considered. The proposed approach holds promise for optimizing low-dose CT protocols across scanner platforms. Full article
(This article belongs to the Special Issue Recent Advance of Machine Learning in Biomedical Image Analysis)
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11 pages, 4648 KiB  
Article
A Finite Element Analysis Study of Edentulous Model with Complete Denture to Simulate Masticatory Movement
by Jeong-Hyeon Lee, Jeong-Hee Seo, Shin-Wook Park, Won-Gi Kim, Tae-Gon Jung and Sung-Jae Lee
Bioengineering 2024, 11(4), 336; https://doi.org/10.3390/bioengineering11040336 (registering DOI) - 29 Mar 2024
Abstract
The purposes of this study are to establish and validate a finite element (FE) model using finite element analysis methods and to identify optimal loading conditions to simulate masticatory movement. A three-dimensional FE model of the maxillary and mandibular cortical bone, cancellous bone, [...] Read more.
The purposes of this study are to establish and validate a finite element (FE) model using finite element analysis methods and to identify optimal loading conditions to simulate masticatory movement. A three-dimensional FE model of the maxillary and mandibular cortical bone, cancellous bone, and gingiva was constructed based on edentulous cone-beam-computed tomography data. Dental computer-aided design software was used to design the denture base and artificial teeth to produce a complete denture. Mesh convergence was performed to derive the optimal mesh size, and validation was conducted through comparison with mechanical test results. The mandible was rotated step-by-step to induce movements similar to actual mastication. Results showed that there was less than a 6% difference between the mechanical test and the alveolar bone-complete denture. It opened 10° as set in the first stage, confirming that the mouth closed 7° in the second stage. Occlusal contact occurred between the upper and lower artificial teeth as the mouth closed the remaining angle of 3° in the third stage while activating the masseter muscle. These results indicate that the FE model and masticatory loading conditions developed in this study can be applied to analyze biomechanical effects according to the wearing of dentures with various design elements applied. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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14 pages, 1811 KiB  
Article
Sulforaphane Ameliorates High-Fat-Diet-Induced Metabolic Abnormalities in Young and Middle-Aged Obese Male Mice
by Jing Luo, Hana Alkhalidy, Zhenquan Jia and Dongmin Liu
Foods 2024, 13(7), 1055; https://doi.org/10.3390/foods13071055 (registering DOI) - 29 Mar 2024
Abstract
Type 2 diabetes (T2D) is still a fast-growing health problem globally. It is evident that chronic insulin resistance (IR) and progressive loss of β-cell mass and function are key features of T2D etiology. Obesity is a leading pathogenic factor for developing IR. The [...] Read more.
Type 2 diabetes (T2D) is still a fast-growing health problem globally. It is evident that chronic insulin resistance (IR) and progressive loss of β-cell mass and function are key features of T2D etiology. Obesity is a leading pathogenic factor for developing IR. The aim of the present study was to determine whether sulforaphane (SFN), a natural compound derived from cruciferous vegetables, can prevent (prevention approach) or treat (treatment approach) obesity and IR in mouse models. We show that dietary intake of SFN (0.5 g/kg of HFD) for 20 weeks suppressed high-fat diet (HFD)-induced fat accumulation by 6.04% and improved insulin sensitivity by 23.66% in young male mice. Similarly, dietary provision of SFN (0.25 g/kg) significantly improved blood lipid profile, glucose tolerance, and insulin sensitivity of the middle-aged male mice while it had little effects on body composition as compared with the HFD group. In the treatment study, oral administration of SFN (40 mg/kg) induced weight loss and improved insulin sensitivity and plasma lipid profile in the diet-induced-obesity (DIO) male mice. In all three studies, the metabolic effects of SFN administration were not associated with changes in food intake. In vitro, SFN increased glucose uptake in C2C12 myotubes and increased fatty acid and pyruvate oxidation in primary human skeletal muscle cells. Our results suggest that SFN may be a naturally occurring insulin-sensitizing agent that is capable of improving the metabolic processes in HFD-induced obesity and IR and thereby may be a promising compound for T2D prevention. Full article
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15 pages, 3463 KiB  
Article
Design Considerations for Continuous Wave Intracavity Backwards Optical Parametric Oscillators
by Josh Kneller, Liam Flannigan and Chang-Qing Xu
Photonics 2024, 11(4), 318; https://doi.org/10.3390/photonics11040318 (registering DOI) - 29 Mar 2024
Abstract
In this paper, we report a theoretical systematic study of continuous wave intracavity backwards optical parametric oscillators based on periodically poled lithium niobate (PPLN) for mid-infrared (mid-IR) light generation. We study the effects of varying different cavity parameters including nonlinear crystal length, cavity [...] Read more.
In this paper, we report a theoretical systematic study of continuous wave intracavity backwards optical parametric oscillators based on periodically poled lithium niobate (PPLN) for mid-infrared (mid-IR) light generation. We study the effects of varying different cavity parameters including nonlinear crystal length, cavity size, pump laser diode spot size, output coupler radius, and cavity loss values on the output power and threshold of the proposed mid-IR laser. The effects of different physical phenomena are included in the model including pump depletion due to the nonlinear conversion process, the thermal lens effect, and mode overlap between the beams in the nonlinear crystal. We show that high output powers in the mid infrared (>500 mW at 3.2 μm) can be achieved with proper cavity design and that a laser threshold with a PPLN as short as 2 cm can be reached. Full article
(This article belongs to the Special Issue Recent Advances in Laser Beams)
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14 pages, 1065 KiB  
Review
Testicular Vascularization after Pediatric Inguinal Hernia Repair: A Systematic Review and Meta-Analysis
by Roxanne Eurlings, Rianne E. M. Killaars, Ruben G. J. Visschers and Wim G. van Gemert
Children 2024, 11(4), 409; https://doi.org/10.3390/children11040409 (registering DOI) - 29 Mar 2024
Abstract
Background: The effect of pediatric inguinal hernia repair (IHR) on testicular vascularization remains unclear. Manipulating the spermatic cord during surgery may reduce blood flow due to edema and vasoconstriction. This can lead to testicular atrophy. The study aims to review current knowledge of [...] Read more.
Background: The effect of pediatric inguinal hernia repair (IHR) on testicular vascularization remains unclear. Manipulating the spermatic cord during surgery may reduce blood flow due to edema and vasoconstriction. This can lead to testicular atrophy. The study aims to review current knowledge of testicular vascular impairment following IHR in children. Methods: A systematic literature search was conducted in PubMed/Medline, Embase, Cochrane Library, and Web of Science. Methodological quality was assessed using validated tools. Data were extracted, and a pooled data analysis was performed. Results: Ten studies were included in the systematic review. Six of these studies were eligible for meta-analysis. This revealed a significant decrease in testicular vascularization during the short-term follow-up (1 day–1 week) after IHR using the open surgical approach. This decrease was not present after laparoscopic intervention. There was no more increased resistance in the vessels at long-term follow-up (1 month–6 months), suggesting that the impaired vascularity is only temporary. Conclusions: There seems to be a short-term transient vascular impairment of the testis after open IHR in children. This might be of clinical relevance to prefer the laparoscopic approach for IHR in children, even though the open approach is the gold standard, in contrast to adult IHR. The impact on testicular function and sperm quality later in life remains unclear. Comparative studies of both techniques are needed to determine if there is a significant difference in testicular vascularity. Long-term studies are necessary to assess the impact of transiently reduced vascularity on sperm quality and fertility later in life. Full article
(This article belongs to the Section Pediatric Surgery)
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