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19 pages, 1711 KiB  
Review
The Role of Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer
by Kyounghyun Kim
Int. J. Mol. Sci. 2024, 25(7), 3818; https://doi.org/10.3390/ijms25073818 (registering DOI) - 29 Mar 2024
Abstract
The aryl hydrocarbon receptor (AHR) serves as a ligand-activated transcription factor crucial for regulating fundamental cellular and molecular processes, such as xenobiotic metabolism, immune responses, and cancer development. Notably, a spectrum of endocrine-disrupting chemicals (EDCs) act as agonists or antagonists of AHR, leading [...] Read more.
The aryl hydrocarbon receptor (AHR) serves as a ligand-activated transcription factor crucial for regulating fundamental cellular and molecular processes, such as xenobiotic metabolism, immune responses, and cancer development. Notably, a spectrum of endocrine-disrupting chemicals (EDCs) act as agonists or antagonists of AHR, leading to the dysregulation of pivotal cellular and molecular processes and endocrine system disruption. Accumulating evidence suggests a correlation between EDC exposure and the onset of diverse pancreatic diseases, including diabetes, pancreatitis, and pancreatic cancer. Despite this association, the mechanistic role of AHR as a linchpin molecule in EDC exposure-related pathogenesis of pancreatic diseases and cancer remains unexplored. This review comprehensively examines the involvement of AHR in EDC exposure-mediated regulation of pancreatic pathogenesis, emphasizing AHR as a potential therapeutic target for the pathogenesis of pancreatic diseases and cancer. Full article
(This article belongs to the Special Issue Endocrine Disruption and Human Diseases 2.0)
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5 pages, 3101 KiB  
Interesting Images
Arterial Calcification Disappearance in Breast Imaging: A Key Indicator for Transition to Invasive Ductal Carcinoma
by Arisa Sato, Tomoyuki Fujioka, Iichiroh Onishi, Emi Yamaga, Leona Katsuta, Kazunori Kubota, Yuichi Kumaki, Toshiyuki Ishiba, Goshi Oda and Ukihide Tateishi
Diagnostics 2024, 14(7), 727; https://doi.org/10.3390/diagnostics14070727 (registering DOI) - 29 Mar 2024
Abstract
A woman in her 70s, initially suspected of having fibroadenoma due to a well-defined mass in her breast, underwent regular mammography and ultrasound screenings. Over several years, no appreciable alterations in the mass were observed, maintaining the fibroadenoma diagnosis. However, in the fourth [...] Read more.
A woman in her 70s, initially suspected of having fibroadenoma due to a well-defined mass in her breast, underwent regular mammography and ultrasound screenings. Over several years, no appreciable alterations in the mass were observed, maintaining the fibroadenoma diagnosis. However, in the fourth year, an ultrasound indicated slight enlargement and peripheral irregularities in the mass, even though the mammography images at that time showed no alterations. Interestingly, mammography images over time showed the gradual disappearance of previously observed arterial calcification around the mass. Pathological examination eventually identified the mass as invasive ductal carcinoma. Although the patient had breast tissue arterial calcification typical of atherosclerosis, none was present around the tumor-associated arteries. This case highlights the importance of monitoring arterial calcification changes in mammography, suggesting that they are crucial indicators in breast cancer diagnosis, beyond observing size and shape alterations. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
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16 pages, 20102 KiB  
Article
Joint Estimation of SOC and SOH for Lithium-Ion Batteries Based on Dual Adaptive Central Difference H-Infinity Filter
by Bingyu Sang, Zaijun Wu, Bo Yang, Junjie Wei and Youhong Wan
Energies 2024, 17(7), 1640; https://doi.org/10.3390/en17071640 (registering DOI) - 29 Mar 2024
Abstract
The accurate estimation of the state-of-charge (SOC) and state-of-health (SOH) of lithium-ion batteries is crucial for the safe and reliable operation of battery systems. In order to overcome the practical problems of low accuracy, slow convergence and insufficient robustness in the existing joint [...] Read more.
The accurate estimation of the state-of-charge (SOC) and state-of-health (SOH) of lithium-ion batteries is crucial for the safe and reliable operation of battery systems. In order to overcome the practical problems of low accuracy, slow convergence and insufficient robustness in the existing joint estimation algorithms of SOC and SOH, a Dual Adaptive Central Difference H-Infinity Filter algorithm is proposed. Firstly, the Forgetting Factor Recursive Least Squares (FFRLS) algorithm is employed for parameter identification, and an inner loop with multiple updates of the parameter estimation vector is added to improve the accuracy of parameter identification. Secondly, the capacity is selected as the characterization of SOH, and the open circuit voltage and capacity are used as the state variables for capacity estimation to improve its convergence speed. Meanwhile, considering the interaction between SOC and SOH, the state space equations of SOC and SOH estimation are established. Moreover, the proposed algorithm introduces a robust discrete H-infinity filter equation to improve the measurement update on the basis of the central differential Kalman filter with good accuracy, and combines the Sage–Husa adaptive filter to achieve the joint estimation of SOC and SOH. Finally, under Urban Dynamometer Driving Schedule (UDDS) and Highway Fuel Economy Test (HWFET) conditions, the SOC estimation errors are 0.5% and 0.63%, and the SOH maximum estimation errors are 0.73% and 0.86%, indicating that the proposed algorithm has higher accuracy compared to the traditional algorithm. The experimental results at different initial values of capacity and SOC demonstrate that the proposed algorithm showcases enhanced convergence speed and robustness. Full article
(This article belongs to the Collection Renewable Energy and Energy Storage Systems)
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22 pages, 1059 KiB  
Systematic Review
Cervical Cancer Associated with Pregnancy: Current Challenges and Future Strategies
by Jennifer Le Guévelou, Lise Selleret, Enora Laas, Fabrice Lecuru and Manon Kissel
Cancers 2024, 16(7), 1341; https://doi.org/10.3390/cancers16071341 (registering DOI) - 29 Mar 2024
Abstract
Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer without [...] Read more.
Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer without compromising its chances for cure, while preserving the pregnancy and the health of the fetus and child. To date, guidelines for gynecological cancers are provided through international consensus meetings with expert panels, giving insights on both diagnosis, treatment, and obstetrical care. However, these expert guidelines do not discuss the various approaches than can be found within the literature, such as alternative staging modalities or innovative surgical approaches. Also, the obstetrical care of women diagnosed with cervical cancer during pregnancy requires specific considerations that are not provided within our current standard of care. This systematic review aims to fill the gap on current issues with regards to the management of cervical cancer during pregnancy and provide future directions within this evolving landscape. Full article
(This article belongs to the Special Issue Cervical Cancer: Screening and Treatment in 2024)
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20 pages, 7774 KiB  
Article
Automatic Martian Polar Ice Cap Extraction Algorithm for Remote Sensing Data and Analysis of Their Spatiotemporal Variation Characteristics
by Weiye Xu, Zhulin Chen, Huifang Zhang, Kun Jia, Degyi Yangzom, Xiang Zhao, Yunjun Yao and Xiaotong Zhang
Remote Sens. 2024, 16(7), 1201; https://doi.org/10.3390/rs16071201 (registering DOI) - 29 Mar 2024
Abstract
The detection of Martian polar ice cap change patterns is important for understanding their effects on driving Mars’s global water cycle and for regulating atmospheric circulation. However, current Martian ice cap identification using optical remote sensing data mainly relies on visual interpretation, which [...] Read more.
The detection of Martian polar ice cap change patterns is important for understanding their effects on driving Mars’s global water cycle and for regulating atmospheric circulation. However, current Martian ice cap identification using optical remote sensing data mainly relies on visual interpretation, which makes it difficult to quickly extract ice caps from multiple images and analyze their fine-scale spatiotemporal variation characteristics. Therefore, this study proposes an automatic Martian polar ice cap extraction algorithm for remote sensing data and analyzes the dynamic change characteristics of the Martian North Pole ice cap using time-series data. First, the automatic Martian ice cap segmentation algorithm was developed based on the ice cap features of high reflectance in the blue band and low saturation in the RGB band. Second, the Martian North Pole ice cap was extracted for the three Martian years MY25, 26, and 28 using Mars Orbiter Camera (MOC) Mars Daily Global Maps (MDGMs) data, which had better spatiotemporal continuity to analyze its variation characteristics. Lastly, the spatiotemporal variation characteristics of the ice cap and the driving factors of ice cap ablation were explored for the three aforementioned Martian years. The results indicated that the proposed automatic ice cap extraction algorithm had good performance, and the classification accuracy exceeded 93%. The ice cap ablation boundary retreat rates and spatiotemporal distributions were similar for the three years, with approximately 105 km2 of ice cap ablation for every one degree of areocentric longitude of the Sun (Ls). The main driving factor of ice cap ablation was solar radiation, which was mainly related to Ls. In addition, elevation had a different effect on ice cap ablation at different Ls in the same latitude area near the ablation boundary of the ice cap. Full article
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16 pages, 6827 KiB  
Article
Comparative Genomic Analysis of PEBP Genes in Cucurbits Explores the Interactors of Cucumber CsPEBPs Related to Flowering Time
by Lianxue Fan, Ziyi Zhu, Xiaoru Lin, Xia Shen, Tianjiao Yang, Haixin Wang and Xiuyan Zhou
Int. J. Mol. Sci. 2024, 25(7), 3815; https://doi.org/10.3390/ijms25073815 (registering DOI) - 29 Mar 2024
Abstract
The family of phosphatidylethanolamine-binding proteins (PEBPs) participates in various plant biological processes, mainly flowering regulation and seed germination. In cucurbit crops, several PEBP genes have been recognized to be responsible for flowering time. However, the investigation of PEBP family members across the genomes [...] Read more.
The family of phosphatidylethanolamine-binding proteins (PEBPs) participates in various plant biological processes, mainly flowering regulation and seed germination. In cucurbit crops, several PEBP genes have been recognized to be responsible for flowering time. However, the investigation of PEBP family members across the genomes of cucurbit species has not been reported, and their conservation and divergence in structure and function remain largely unclear. Herein, PEBP genes were identified from seven cucurbit crops and were used to perform a comparative genomics analysis. The cucurbit PEBP proteins could be classified into MFT, FT, TFL, and PEBP clades, and further, the TFL clade was divided into BFT-like, CEN-like, and TFL1-like subclades. The MFT-like, FT-like, and TFL-like proteins were clearly distinguished by a critical amino acid residue at the 85th position of the Arabidopsis FT protein. In gene expression analysis, CsaPEBP1 was highly expressed in flowers, and its expression levels in females and males were 70.5 and 89.2 times higher, respectively, than those in leaves. CsaPEBP5, CsaPEBP6, and CsaPEBP7 were specifically expressed in male flowers, with expression levels 58.1, 17.3, and 15.7 times higher, respectively, than those of leaves. At least five CsaPEBP genes exhibited the highest expression during the later stages of corolla opening. Through clustering of time-series-based RNA-seq data, several potential transcription factors (TFs) interacting with four CsaPEBPs were identified during cucumber corolla opening. Because of the tandem repeats of binding sites in promoters, NF-YB (Csa4G037610) and GATA (Csa7G64580) TFs appeared to be better able to regulate the CsaPEBP2 and CsaPEBP5 genes, respectively. This study would provide helpful information for further investigating the roles of PEBP genes and their interacting TFs in growth and development processes, such as flowering time regulation in cucurbit crops. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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12 pages, 1624 KiB  
Article
Rice Stripe Virus Infection Facilitates the Reproductive Potential of Laodelphax striatellus
by Yuanyuan Zhang, Youxin Yu, Meiqi Xu, Jingyan Liao, Chenjia Shao, Liran Fu, Mingshi Qian, Gang Xu and Guoqing Yang
Agronomy 2024, 14(4), 714; https://doi.org/10.3390/agronomy14040714 (registering DOI) - 29 Mar 2024
Abstract
The rice stripe virus (RSV) is transmitted by the small brown planthopper Laodelphax striatellus in a persistent and circulative–propagative manner. During the last few decades, RSV has caused serious disease outbreaks in rice fields in China. The results of long-term coevolution have led [...] Read more.
The rice stripe virus (RSV) is transmitted by the small brown planthopper Laodelphax striatellus in a persistent and circulative–propagative manner. During the last few decades, RSV has caused serious disease outbreaks in rice fields in China. The results of long-term coevolution have led to complex and diverse relationships between viruses and vector insects, and understanding these interactions is critical for the management of diseases and vector organisms. In this study, three groups of comparative experiments were performed to investigate the effects of RSV infection on the reproductive parameters, vitellogenin (Vg), and Vg receptor (VgR) expressions of L. striatellus. The results showed that RSV infection promoted the fecundity, hatchability, and Vg and VgR expressions of L. striatellus but had no effect on the preoviposition period and oviposition period. Furthermore, the RNA interference of the nucleocapsid protein (CP) gene and the injection of the CP antibody in RSV-viruliferous L. striatellus reduced the fecundity, hatchability, and Vg and VgR expressions, further strengthening the hypothesis that RSV may manipulate the reproductive behavior of insect vectors to promote its own transmission. The results of this study can further reveal the interaction mechanism of virus–vector insects in reproduction and virus transmission, and provide new insights for the control of insect-borne viruses. Full article
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13 pages, 2359 KiB  
Article
Locating Electrified Aircraft Service to Reduce Urban Congestion
by Raj Bridgelall
Information 2024, 15(4), 186; https://doi.org/10.3390/info15040186 (registering DOI) - 29 Mar 2024
Abstract
The relentless expansion of urban populations and the surge in e-commerce have increased the demand for rapid delivery services, leading to an increase in truck traffic that contributes to urban congestion, environmental pollution, and economic inefficiencies. The critical challenge this poses is not [...] Read more.
The relentless expansion of urban populations and the surge in e-commerce have increased the demand for rapid delivery services, leading to an increase in truck traffic that contributes to urban congestion, environmental pollution, and economic inefficiencies. The critical challenge this poses is not only in managing urban spaces efficiently but also in aligning with global sustainability goals. This study addresses the pressing need for innovative solutions to reduce reliance on truck transportation in congested urban areas without compromising the efficiency of freight delivery systems. This study contributes a novel approach that leverages electrified and autonomous aircraft (EAA) cargo shuttles to shift the bulk of air transportable freight from road to air, specifically targeting underutilized airports and establishing vertiports in remote locations. By applying data mining techniques to analyze freight flow data, this research identifies key commodity categories and metropolitan statistical areas (MSAs) where the implementation of EAA services could significantly mitigate truck-induced congestion. The findings reveal that targeting a select few commodities and MSAs can potentially decrease truck traffic, with electronics emerging as the dominant commodity category, and cities like Los Angeles and Chicago as prime candidates for initial EAA service deployment. Stakeholders in urban planning, transportation logistics, and environmental policy will find this study’s insights beneficial. This work lays a foundation for future innovations in sustainable urban mobility and logistics. Full article
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10 pages, 1400 KiB  
Article
The Role of Climatic, Environmental and Socioeconomic Factors in the Natural Movement of Urban Populations in Kazakhstan, 2012–2020: An Analysis from a Middle-Income Country in Central Asia
by Nurlan Smagulov, Olzhas Zhamantayev, Aiman Konkabayeva, Ainur Adilbekova, Gulmira Zhanalina, Nurzhamal Shintayeva and Dinara Aubakirova
Int. J. Environ. Res. Public Health 2024, 21(4), 416; https://doi.org/10.3390/ijerph21040416 (registering DOI) - 29 Mar 2024
Abstract
Background: This study addresses the importance of identifying key characteristics influencing demographic indicators for urban populations, emphasizing the need to consider regional climatic features and ecological factors. The research utilized data from ten main regional cities across the Republic of Kazakhstan. Methods: This [...] Read more.
Background: This study addresses the importance of identifying key characteristics influencing demographic indicators for urban populations, emphasizing the need to consider regional climatic features and ecological factors. The research utilized data from ten main regional cities across the Republic of Kazakhstan. Methods: This study involved a retrospective analysis based on secondary data from official sources spanning 2012–2020. We employed correlation analysis and multidimensional regression models. Results: Noteworthy predictors for crude birth rate included the influence of effective temperature (β = 0.842, p < 0.0001), marriage rate (β = 0.780, p < 0.0001), Gini coefficient (β = −27.342, p = 0.020) and divorce rate (β = −2.060, p < 0.0001), with overall strong model performance (R2 = 0.940). The degree of atmospheric pollution (β = −0.949, p = 0.044), effective temperature (β = −0.294, p < 0.0001) and Gini coefficient (β = 19.923, p = 0.015) were the predictors for crude mortality rate, with a high model fit (R2 = 0.796). Conclusions: The study unveils significant relationships between demographic indicators (crude birth rate, mortality rate) and variables like effective temperature, marriage rate, divorce rate, Gini coefficient, physician density and others. This analysis of climatic, environmental, and socioeconomic factors influencing demographic indicators may help in promoting specific measures to address public health issues in Kazakhstan. Full article
(This article belongs to the Section Environmental Health)
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14 pages, 2348 KiB  
Article
Jitter Measurements of 1 cm2 LGADs for Space Experiments
by Ashish Bisht, Leo Cavazzini, Matteo Centis Vignali, Fabiola Caso, Omar Hammad Ali, Francesco Ficorella, Maurizio Boscardin and Giovanni Paternoster
Instruments 2024, 8(2), 27; https://doi.org/10.3390/instruments8020027 (registering DOI) - 29 Mar 2024
Abstract
This work explores the possibility of using Low Gain Avalanche Diodes (LGADs) for tracker-based experiments studying Charged Cosmic Rays (CCRs) in space. While conventional silicon microstrip sensors provide only spatial information about the charged particle passing through the tracker, LGADs have the potential [...] Read more.
This work explores the possibility of using Low Gain Avalanche Diodes (LGADs) for tracker-based experiments studying Charged Cosmic Rays (CCRs) in space. While conventional silicon microstrip sensors provide only spatial information about the charged particle passing through the tracker, LGADs have the potential to provide additional timing information with a resolution in the order of tens of picoseconds. For the first time, it has been demonstrated that an LGAD with an active area of approximately 1 cm2 can achieve a jitter of less than 40 ps. A comparison of design and gain layers is carried out to understand which provides the best time resolution. For this purpose, laboratory measurements of sensors’ electrical properties and gain using LED and an Infrared laser, as well as their jitter, were performed. Full article
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17 pages, 1987 KiB  
Review
ORAI Ca2+ Channels in Cancers and Therapeutic Interventions
by Qian Zhang, Chen Wang and Lian He
Biomolecules 2024, 14(4), 417; https://doi.org/10.3390/biom14040417 (registering DOI) - 29 Mar 2024
Abstract
The ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling pathways. Dysregulated calcium homeostasis arising from mutations and post-translational modifications in ORAI can lead to immune disorders, myopathy, cardiovascular diseases, and even cancers. Small [...] Read more.
The ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling pathways. Dysregulated calcium homeostasis arising from mutations and post-translational modifications in ORAI can lead to immune disorders, myopathy, cardiovascular diseases, and even cancers. Small molecules targeting ORAI present an approach for calcium signaling modulation. Moreover, emerging techniques like optogenetics and optochemistry aim to offer more precise regulation of ORAI. This review focuses on the role of ORAI in cancers, providing a concise overview of their significance in the initiation and progression of cancers. Additionally, it highlights state-of-the-art techniques for ORAI channel modulation, including advanced optical tools, potent pharmacological inhibitors, and antibodies. These novel strategies offer promising avenues for the functional regulation of ORAI in research and may inspire innovative approaches to cancer therapy targeting ORAI. Full article
(This article belongs to the Special Issue Role of STIM and Orai in Calcium Signaling)
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14 pages, 732 KiB  
Review
Prebiotic Strategies to Manage Lactose Intolerance Symptoms
by Gloria Angima, Yunyao Qu, Si Hong Park and David C. Dallas
Nutrients 2024, 16(7), 1002; https://doi.org/10.3390/nu16071002 (registering DOI) - 29 Mar 2024
Abstract
Lactose intolerance, which affects about 65–75% of the world’s population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, [...] Read more.
Lactose intolerance, which affects about 65–75% of the world’s population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, namely lactase persistence, allow some individuals to metabolize lactose effectively post-weaning, a trait thought to be an evolutionary adaptation to dairy consumption. Although lactase non-persistence cannot be altered by diet, prebiotic strategies, including the consumption of galactooligosaccharides (GOSs) and possibly low levels of lactose itself, may shift the microbiome and mitigate symptoms of lactose consumption. This review discusses the etiology of lactose intolerance and the efficacy of prebiotic approaches like GOSs and low-dose lactose in symptom management. Full article
(This article belongs to the Special Issue Nutritional Support for Pediatric Gastroenterology Patients)
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14 pages, 3491 KiB  
Article
Interplay of Isomorphs and Polymorphs of Amidino-Copper(II) Complexes with Different Halides
by Zaina Yamba, Anna Peoble, Egor M. Novikov, Raúl Casta?eda and Tatiana V. Timofeeva
Crystals 2024, 14(4), 319; https://doi.org/10.3390/cryst14040319 (registering DOI) - 29 Mar 2024
Abstract
To increase the number of potential materials for application as MRI contrast agents, several Cu(II) complexes were synthesized. Cu(II) complexes were chosen because they are less expensive in comparison with the presently used Gd(III), Mn(II) and other agents. Pyridine-2-carboximidamide (1), pyrimidine-2-carboximidamide [...] Read more.
To increase the number of potential materials for application as MRI contrast agents, several Cu(II) complexes were synthesized. Cu(II) complexes were chosen because they are less expensive in comparison with the presently used Gd(III), Mn(II) and other agents. Pyridine-2-carboximidamide (1), pyrimidine-2-carboximidamide (2) and pyrazole-2-carboximidamide (3) in the form of different salts along with CuCl2 and NaCl or CuBr2 and NaBr were used to obtain four Cu(II) complexes: dichloro-pyrimidine-2-carboximidamide copper(II) (4), dibromo-pyrimidine-2-carboximidamide copper(II) (5), dichloro-pirazole-2-carboximidamide copper(II) (6), and dibromo-pirazole-2-carboximidamide copper(II) (7). X-ray diffraction analysis revealed that molecular complexes 47 contain square planar coordinated Cu(II) atoms and their structures are very similar, as well as their packing in crystals, which allows us to consider them isomorphs. The same synthetic approach to complex preparation where NaCl or NaBr was not used brought us to the formation of dimeric complexes μ-chloro{chloro(pyridine-2-carboximidamide)copper(II)} (8) and μ-chloro{chloro(pyrimidine-2-carboximidamide)copper(II)} (9). In the dimeric complexes, two fragments which were the same as in monomeric complexes 47 are held together by bridging Cu-Cl bonds making the coordination of Cu equal to 5 (square pyramid). In dimeric complexes, axial Cu-Cl bonds are 2.7360 and 2.854 Å. These values are Cu-Cl bonds on the edge of existence according to statistical data from CSD. Synthesized complexes were characterized by IR spectroscopy, TGA, PXRD, EPR, and quantum chemical calculations. The higher thermal stability of monomer pyrimidine-based complexes with Cl and Br substituents makes them more prospective for further studies. Full article
(This article belongs to the Special Issue Intermolecular Interactions in Macromolecular Complexes)
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11 pages, 2479 KiB  
Article
Antihistamine Medication Blunts Localized-Vibration-Induced Increases in Popliteal Blood Flow
by Devin Needs, Jonathan Blotter, Gilbert W. Fellingham, Glenn Cruse, Jayson R. Gifford, Aaron Wayne Johnson and Jeffrey Brent Feland
Vibration 2024, 7(2), 351-361; https://doi.org/10.3390/vibration7020017 (registering DOI) - 29 Mar 2024
Abstract
Localized vibration (LV) of the lower leg increases arterial blood flow (BF). However, it is unclear how LV causes this increase. Understanding the mechanisms of this response could lead to the optimized future use of LV as a therapy. One possible mechanism of [...] Read more.
Localized vibration (LV) of the lower leg increases arterial blood flow (BF). However, it is unclear how LV causes this increase. Understanding the mechanisms of this response could lead to the optimized future use of LV as a therapy. One possible mechanism of LV-mediated BF is through histamine release by mechanosensitive mast cells. The purpose of this study was to measure the BF response of 21 recreationally active young adults (11 male, 10 female, mean age 22.1 years) after 47 Hz and 10 min LV to the calf, with and without antihistamine medication (180 mg Fexofenadine). Each participant received both control (no antihistamine) and antihistamine (treatment) conditions separated by at least 24 h. BF ultrasound measurements (mean and peak blood velocity, volume flow, popliteal diameter, and heart rate) were taken before LV therapy and periodically for 19 min post LV. Using a cell means mixed model, we found that LV significantly increased the control mean blood velocity immediately post LV but did not significantly increase the antihistamine mean blood velocity immediately post LV. Therefore, we hypothesize that a primary mechanism of LV increase in BF is histamine release from mechano-sensing mast cells, and that this response is force-dependent. Full article
(This article belongs to the Special Issue Feature Papers in Vibration)
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11 pages, 872 KiB  
Article
Teaming up Radio and Sub-mm/FIR Observations to Probe Dusty Star-Forming Galaxies
by Meriem Behiri, Marika Giulietti, Vincenzo Galluzzi, Andrea Lapi, Elisabetta Liuzzo and Marcella Massardi
Galaxies 2024, 12(2), 14; https://doi.org/10.3390/galaxies12020014 (registering DOI) - 29 Mar 2024
Abstract
In this paper, we investigate the benefits of teaming up data from the radio to the far-infrared (FIR) regime for the characterization of dusty star-forming galaxies (DSFGs). These galaxies are thought to be the star-forming progenitors of local massive quiescent galaxies and to [...] Read more.
In this paper, we investigate the benefits of teaming up data from the radio to the far-infrared (FIR) regime for the characterization of dusty star-forming galaxies (DSFGs). These galaxies are thought to be the star-forming progenitors of local massive quiescent galaxies and to play a pivotal role in the reconstruction of the cosmic star formation rate density up to high redshift. Due to their dust-enshrouded nature, DSFGs are often invisible in the near-infrared/optical/UV bands. Therefore, they necessitate observations at longer wavelengths, primarily the FIR band, where dust emission occurs, and the radio band, which is not affected by dust absorption. Combining data from these two spectral windows makes it possible to characterize even the dustiest objects, enabling the retrieval of information about their age, dust temperature, and star-formation status, and facilitates the differentiation between various galaxy populations that evolve throughout cosmic history. Despite the detection of faint radio sources being a challenging task, this study demonstrates that an effective strategy to build statistically relevant samples of DSFGs would be reaching deep sensitivities in the radio band, even restricted to smaller areas, and then combining these radio observations with FIR/submm data. Additionally, this paper quantifies the improvement in the spectral energy distribution (SED) reconstruction of DSFGs by incorporating ALMA band measurements, in particular, in its upgraded status thanks to the anticipated Wideband Sensitivity Upgrade. Full article
(This article belongs to the Special Issue The Observation and Detection of Dusty Star-Forming Galaxies)
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36 pages, 5570 KiB  
Review
Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review
by Alexey V. Yaremenko, Nadezhda A. Pechnikova, Konstantinos Porpodis, Savvas Damdoumis, Amalia Aggeli, Papamitsou Theodora and Kalliopi Domvri
J. Pers. Med. 2024, 14(4), 368; https://doi.org/10.3390/jpm14040368 (registering DOI) - 29 Mar 2024
Abstract
Fetal lung development is a crucial and complex process that lays the groundwork for postnatal respiratory health. However, disruptions in this delicate developmental journey can lead to fetal lung development disorders, impacting neonatal outcomes and potentially influencing health outcomes well into adulthood. Recent [...] Read more.
Fetal lung development is a crucial and complex process that lays the groundwork for postnatal respiratory health. However, disruptions in this delicate developmental journey can lead to fetal lung development disorders, impacting neonatal outcomes and potentially influencing health outcomes well into adulthood. Recent research has shed light on the intriguing association between fetal lung development disorders and the development of adult diseases. Understanding these links can provide valuable insights into the developmental origins of health and disease, paving the way for targeted preventive measures and clinical interventions. This review article aims to comprehensively explore the association of fetal lung development disorders with adult diseases. We delve into the stages of fetal lung development, examining key factors influencing fetal lung maturation. Subsequently, we investigate specific fetal lung development disorders, such as respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and other abnormalities. Furthermore, we explore the potential mechanisms underlying these associations, considering the role of epigenetic modifications, transgenerational effects, and intrauterine environmental factors. Additionally, we examine the epidemiological evidence and clinical findings linking fetal lung development disorders to adult respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and other respiratory ailments. This review provides valuable insights for healthcare professionals and researchers, guiding future investigations and shaping strategies for preventive interventions and long-term care. Full article
(This article belongs to the Section Disease Biomarker)
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17 pages, 1176 KiB  
Article
Genetic Potential of Newly Developed Maize Hybrids under Different Water-Availability Conditions in an Arid Environment
by Youstina S. A. Sedhom, Hassan A. Rabie, Hassan A. Awaad, Maryam M. Alomran, Salha M. ALshamrani, Elsayed Mansour and Mohamed M. A. Ali
Life 2024, 14(4), 453; https://doi.org/10.3390/life14040453 (registering DOI) - 29 Mar 2024
Abstract
Drought is a crucial environmental stress that tremendously impacts maize production, particularly under abrupt climate changes. Consequently, breeding drought-tolerant and high-yielding maize hybrids has become decisive in sustaining its production and ensuring global food security under the global fast-growing population. The present study [...] Read more.
Drought is a crucial environmental stress that tremendously impacts maize production, particularly under abrupt climate changes. Consequently, breeding drought-tolerant and high-yielding maize hybrids has become decisive in sustaining its production and ensuring global food security under the global fast-growing population. The present study aimed to explore drought tolerance and agronomic performance of newly developed maize inbred lines and their hybrids. Ten newly developed maize inbred lines were crossed with two high-yielding testers using a line × tester mating design. The developed twenty hybrids alongside two high-yielding commercial hybrids were evaluated under water-deficit (5411 m3/ha) and well-watered (7990 m3/ha) conditions in dry summer climate conditions. Highly significant variations were detected among the evaluated hybrids for all studied agronomic traits under well-watered and water-deficit conditions. The inbred lines L10 and L6 were particularly notable, demonstrating the most significant negative general combining ability (GCA) effects for earliness, which is crucial for stress avoidance in both environmental settings. Inbred lines L11, L7, L6, and L1 also showed the highest positive and most significant GCA effects for key yield traits, indicating their potential as parents in breeding programs. The crosses L-10×T-1 and L-6×T-2 were outstanding for their heterotic effects on earliness in days to tasseling and silking. Similarly, the crosses L-4×T-2 and L-1×T-1 excelled in plant and ear heights under both irrigation regimes. The hybrids L-1×T-2 and L-7×T-1 demonstrated superior heterosis for chlorophyll content, number of rows per ear, and overall grain yield. Additionally, hybrids L-11×T-1 and L-11×T-2 exhibited remarkable heterotic effects for the number of grains per row, number of rows per ear, 100-kernel weight, and grain yield, highlighting their potential in breeding for productivity. Based on drought tolerance indices and cluster analysis, the cross combinations L-11×T-1, L-11×T-2, L-7×T-1, and L-1×T-2 were classified as the most drought-tolerant crosses. The principal component analysis highlighted traits such as days to tasseling, days to silking, chlorophyll content, plant height, ear height, number of grains per row, number of rows per ear, and 100-kernel weight can be taken as selection criteria for improving grain yield in maize breeding programs under limited water conditions. Based on the summarized results, the identified genetic materials could be considered promising under both conditions and hold potential for future breeding programs. Full article
(This article belongs to the Special Issue Cereals: Stress Resistance and Breeding)
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8 pages, 188 KiB  
Editorial
Yellow River Basin Management under Pressure: Present State, Restoration and Protection II: Lessons from a Special Issue
by Qiting Zuo, Xiangyi Ding, Guotao Cui and Wei Zhang
Water 2024, 16(7), 999; https://doi.org/10.3390/w16070999 (registering DOI) - 29 Mar 2024
Abstract
This Special Issue is the second edition following the publication of the first Issue, “Yellow River Basin Management under Pressure: Present State, Restoration and Protection”, in 2021 [...] Full article
16 pages, 494 KiB  
Article
Crowdfunding versus Traditional Banking: Alternative or Complementary Systems for Financing Projects in Portugal?
by Bruno Torres, Zélia Serrasqueiro and Márcio Oliveira
Int. J. Financial Stud. 2024, 12(2), 33; https://doi.org/10.3390/ijfs12020033 (registering DOI) - 29 Mar 2024
Abstract
In an era where crowdfunding in Portugal is garnering increased public attention, exemplified by notable campaigns like the recent funding of the nurses’ strike, we explore its potential as an alternative financial source to traditional banking. Through a comprehensive case study, we delve [...] Read more.
In an era where crowdfunding in Portugal is garnering increased public attention, exemplified by notable campaigns like the recent funding of the nurses’ strike, we explore its potential as an alternative financial source to traditional banking. Through a comprehensive case study, we delve into pertinent issues, encompassing European legislation, market dynamics, and a survey disseminated to representatives of the four prominent Portuguese crowdfunding platforms. Comprising forty-one questions across four categories, the survey extracts insights on platform details, company/project information, investor perspectives, and the financing process, along with an evaluation of platform advantages/disadvantages vis-à-vis traditional banking. Despite heightened visibility, crowdfunding remains relatively unfamiliar to the broader public, yet it diverges from banking not as a substitute but as a complementary financial mechanism. Emphasizing accessibility, process agility, and reduced bureaucracy, crowdfunding serves as a means of swiftly gaining recognition for a company or project while tapping into a broad audience. Rather than competition, it offers supplementary support, facilitating the identification and validation of investment opportunities and concepts. Moreover, it streamlines subsequent interactions with banks and investors, enhancing confidence in a project’s viability. In essence, crowdfunding emerges not as an alternative but a strategic complement, enriching the financial landscape with its unique attributes. Full article
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28 pages, 4528 KiB  
Article
Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties
by Maria V. Zykova, Kristina A. Bratishko, Evgeny E. Buyko, Lyudmila A. Azarkina, Vladimir V. Ivanov, Dmitrii A. Mihalyov, Evgeniya S. Trofimova, Marina G. Danilets, Anastasia A. Ligacheva, Andrey I. Konstantinov, Alexander A. Ufandeev, Evgenia S. Rabtsevich, Larisa A. Drygunova, Anastasia P. Zima, Sergey R. Bashirov, Elena V. Udut and Mikhail V. Belousov
Molecules 2024, 29(7), 1530; https://doi.org/10.3390/molecules29071530 (registering DOI) - 29 Mar 2024
Abstract
An investigation was carried out on humic substances (HSs) isolated from the coal of the Kansk-Achinsk basin (Krasnoyarsk Territory, Russia). The coal HSs demonstrate the main parameters of molecular structure inherent to this class of natural compounds. An assessment was performed for the [...] Read more.
An investigation was carried out on humic substances (HSs) isolated from the coal of the Kansk-Achinsk basin (Krasnoyarsk Territory, Russia). The coal HSs demonstrate the main parameters of molecular structure inherent to this class of natural compounds. An assessment was performed for the chemical, microbiological, and pharmacological safety parameters, as well as the biological efficacy. The HS sample meets the safety requirements in microbiological purity, toxic metals content (lead, cadmium, mercury, arsenic), and radionuclides. The presence of 11 essential elements was determined. The absence of general, systemic toxicity, cytotoxicity, and allergenic properties was demonstrated. The coal HS sample was classified as a Class V hazard (low danger substances). High antioxidant and antiradical activities and immunotropic and cytoprotective properties were identified. The ability of the HS to inhibit hydroxyl radicals and superoxide anion radicals was revealed. Pronounced actoprotective and nootropic activities were also demonstrated in vivo. Intragastric administration of the HS sample resulted in the improvement of physical parameters in mice as assessed by the “swim exhaustion” test. Furthermore, intragastric administration in mice with cholinergic dysfunction led to a higher ability of animals with scopolamine-induced amnesia to form conditioned reflexes. These findings suggest that the studied HS sample is a safe and effective natural substance, making it suitable for use as a dietary bioactive supplement. Full article
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15 pages, 2558 KiB  
Article
Preparation, Purification, Characterization and Antioxidant Activity of Rice Bran Fermentation Broth with Hypsizigus marmoreus
by Yanping Chi, Lining Kang, Xiangying Liu, Hongrui Sun, Yue Meng, Jialin Zhang, You Kang and Yonggang Dai
Fermentation 2024, 10(4), 188; https://doi.org/10.3390/fermentation10040188 (registering DOI) - 29 Mar 2024
Abstract
The main purpose of this study was to investigate the composition, characterization and antioxidant activity of rice bran fermentation broth, and provide a new way for high-value utilization of rice bran. Firstly, we fermented rice bran with Hypsizigus marmoreus and purified fermentation broth [...] Read more.
The main purpose of this study was to investigate the composition, characterization and antioxidant activity of rice bran fermentation broth, and provide a new way for high-value utilization of rice bran. Firstly, we fermented rice bran with Hypsizigus marmoreus and purified fermentation broth with macroporous resins. We took feruloyl oligosaccharides (FOs) concentration as the measure index, and the results showed that the maximum concentration of FOs was 0.72 mmol/L on the 6th day of rice bran fermentation. We took D101 macroporous resin as adsorption resin for rice bran fermentation broth, and the result showed that FOs concentration reached 2.38 mmol/L with the optimal purification process at pH 4.5, temperature 29 °C, ethanol concentration 55%, sample flow rate 1.5 mL/min, sample concentration 1.7 mL/min and elution flow rate 2.0 mmol/L. Secondly, the characters of rice bran fermentation broth were identified by high-performance liquid chromatography (HPLC) and Fourier-transform infrared spectroscopy (FTIR). These methods showed the presence of ferulic acid (FA), arabinose, xylose and glucose in rice bran fermentation broth. Finally, the in vitro antioxidant activities of rice bran fermentation broth were tested and the result showed that fermentation broth had good antioxidant activities and significantly improved after purification. Full article
(This article belongs to the Special Issue Food Wastes: Feedstock for Value-Added Products: 5th Edition)
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15 pages, 557 KiB  
Article
Prefix Data Augmentation for Contrastive Learning of Unsupervised Sentence Embedding
by Chunchun Wang and Shu Lv
Appl. Sci. 2024, 14(7), 2880; https://doi.org/10.3390/app14072880 (registering DOI) - 29 Mar 2024
Abstract
This paper presents prefix data augmentation (Prd) as an innovative method for enhancing sentence embedding learning through unsupervised contrastive learning. The framework, dubbed PrdSimCSE, uses Prd to create both positive and negative sample pairs. By appending positive and negative prefixes to a sentence, [...] Read more.
This paper presents prefix data augmentation (Prd) as an innovative method for enhancing sentence embedding learning through unsupervised contrastive learning. The framework, dubbed PrdSimCSE, uses Prd to create both positive and negative sample pairs. By appending positive and negative prefixes to a sentence, the basis for contrastive learning is formed, outperforming the baseline unsupervised SimCSE. PrdSimCSE is positioned within a probabilistic framework that expands the semantic similarity event space and generates superior negative samples, contributing to more accurate semantic similarity estimations. The model’s efficacy is validated on standard semantic similarity tasks, showing a notable improvement over that of existing unsupervised models, specifically a 1.08% enhancement in performance on BERTbase. Through detailed experiments, the effectiveness of positive and negative prefixes in data augmentation and their impact on the learning model are explored, and the broader implications of prefix data augmentation are discussed for unsupervised sentence embedding learning. Full article
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26 pages, 991 KiB  
Review
More than Just Bread and Wine: Using Yeast to Understand Inherited Cytochrome Oxidase Deficiencies in Humans
by Chenelle A. Caron-Godon, Emma Collington, Jessica L. Wolf, Genna Coletta and D. Moira Glerum
Int. J. Mol. Sci. 2024, 25(7), 3814; https://doi.org/10.3390/ijms25073814 (registering DOI) - 29 Mar 2024
Abstract
Inherited defects in cytochrome c oxidase (COX) are associated with a substantial subset of diseases adversely affecting the structure and function of the mitochondrial respiratory chain. This multi-subunit enzyme consists of 14 subunits and numerous cofactors, and it requires the function of some [...] Read more.
Inherited defects in cytochrome c oxidase (COX) are associated with a substantial subset of diseases adversely affecting the structure and function of the mitochondrial respiratory chain. This multi-subunit enzyme consists of 14 subunits and numerous cofactors, and it requires the function of some 30 proteins to assemble. COX assembly was first shown to be the primary defect in the majority of COX deficiencies 36 years ago. Over the last three decades, most COX assembly genes have been identified in the yeast Saccharomyces cerevisiae, and studies in yeast have proven instrumental in testing the impact of mutations identified in patients with a specific COX deficiency. The advent of accessible genome-wide sequencing capabilities has led to more patient mutations being identified, with the subsequent identification of several new COX assembly factors. However, the lack of genotype–phenotype correlations and the large number of genes involved in generating a functional COX mean that functional studies must be undertaken to assign a genetic variant as being causal. In this review, we provide a brief overview of the use of yeast as a model system and briefly compare the COX assembly process in yeast and humans. We focus primarily on the studies in yeast that have allowed us to both identify new COX assembly factors and to demonstrate the pathogenicity of a subset of the mutations that have been identified in patients with inherited defects in COX. We conclude with an overview of the areas in which studies in yeast are likely to continue to contribute to progress in understanding disease arising from inherited COX deficiencies. Full article
(This article belongs to the Special Issue Yeast as a Model System to Study Human Diseases)
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