Advancing Open Science
for more than 25 years
Supporting academic communities
since 1996
 
17 pages, 10416 KiB  
Article
Approach and Management of Pregnancies with Risk Identified by Non-Invasive Prenatal Testing
by Miruna Gug, Adrian Ra?iu, Nicoleta Andreescu, Simona Farca?, Sorina Laitin and Cristina Gug
J. Pers. Med. 2024, 14(4), 366; https://doi.org/10.3390/jpm14040366 (registering DOI) - 29 Mar 2024
Abstract
This study represents our second investigation into NIPT, involving a more extensive patient cohort with a specific emphasis on the high-risk group. The high-risk group was subsequently divided into two further groups to compare confirmed cases versus unconfirmed via direct methods. The methodology [...] Read more.
This study represents our second investigation into NIPT, involving a more extensive patient cohort with a specific emphasis on the high-risk group. The high-risk group was subsequently divided into two further groups to compare confirmed cases versus unconfirmed via direct methods. The methodology encompassed the analysis of 1400 consecutive cases from a single genetic center in western Romania, where NIPT was used to assess the risk of specific fetal chromosomal abnormalities. All high-risk cases underwent validation through direct analysis of fetal cells obtained via invasive methods, including chorionic villus sampling and amniocentesis. The confirmation process utilized QF-PCR, karyotyping, and SNP-Array methods customized to each case. Results: A high risk of aneuploidy at NIPT was identified in 36 out of 1400 (2.57%) cases and confirmed in 28 cases. The study also detected an increased risk for copy number variations (CNVs) in 1% of cases, confirmed in two instances involving one large microdeletion and one large microduplication. Trisomy 21 was the exclusive anomaly where NIPT confirmed all cases with identified risk. High-risk NIPT results which were not validated by invasive methods, were classified as false positives; parents in these cases determined to continue the pregnancy. In conclusion, NIPT can serve as a screening method for all pregnancies; however, in high-risk cases, an invasive confirmation test is strongly recommended. Full article
(This article belongs to the Special Issue Personalized Approaches to Prenatal Screening and Diagnosis)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
13 pages, 10917 KiB  
Article
Morphology Characteristics of the Liquid–Vapour Interface in Porous Media
by Yu Zhang and Yi Dong
Appl. Sci. 2024, 14(7), 2881; https://doi.org/10.3390/app14072881 (registering DOI) - 29 Mar 2024
Abstract
The evolution of the liquid–vapour interface plays a crucial role in multiphase flow, heat and mass transfer, and fluid phase change in porous media. A thorough investigation of the interface under varying degrees of saturation is necessary and crucial to fully understanding the [...] Read more.
The evolution of the liquid–vapour interface plays a crucial role in multiphase flow, heat and mass transfer, and fluid phase change in porous media. A thorough investigation of the interface under varying degrees of saturation is necessary and crucial to fully understanding the key mechanism of soil water evaporation. The pore voids and fluids are characterized using X-ray microtomography and image processing. Salt solutions usually replace pure water for better contrast and image development. Machine learning algorithms were employed to identify and extract the different phase and their interface accurately. Then, variations in the geometrical and topological features of the interface at varying saturation during evaporation were analysed to quantitatively describe the connectivity of the liquid phase and the morphological change in the liquid–vapour interface. Topological analysis reveals that normalized Euler characteristic numbers quantify the complementary connectivity of liquid and vapour phase. The curvatures of the liquid–vapour interface of the samples under various saturations classify the liquid–air interface curvature of samples under various saturations for quantitatively describing the migration progress and quantity distribution of typical interface along with drying. Full article
(This article belongs to the Section Civil Engineering)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
10 pages, 1480 KiB  
Article
The Role of Index of Microcirculatory Resistance in Left Anterior Descending Artery ST Segment Elevation Myocardial Infarction Patients after Primary Percutaneous Coronary Intervention
by Seong Huan Choi, Sung Gyun Ahn, Myeong Ho Yoon, Kyoung-Woo Seo, Ki-Jeung Lee, Sung Woo Kwon, Sang-Don Park and Seong-Ill Woo
J. Clin. Med. 2024, 13(7), 1989; https://doi.org/10.3390/jcm13071989 (registering DOI) - 29 Mar 2024
Abstract
Background: Our aim was to assess the relationship of the index of microvascular resistance (IMR) in left anterior descending (LAD) artery involved STEMI patients. Methods: Data of 316 STEMI patients who had undergone primary percutaneous coronary intervention (PCI) were collected from [...] Read more.
Background: Our aim was to assess the relationship of the index of microvascular resistance (IMR) in left anterior descending (LAD) artery involved STEMI patients. Methods: Data of 316 STEMI patients who had undergone primary percutaneous coronary intervention (PCI) were collected from three cardiovascular centers from 2005 to 2015. In total, 246 patients with LAD STEMI were enrolled for IMR evaluation. Patients were divided into two groups respective of the cut-off IMR value of 30. All-cause mortality, left ventricular function, improvement of systolic function, and cardiac biomarkers were analyzed and compared. Results: A total of 246 patients were enrolled. The number of patients in the IMR above 30 group was 93 and below 30 was 153. The mean ages for each group were 57.91 ± 11.99 and 54 ± 10.63, respectively. The peak creatinine kinase (CK) (3936.85 ± 2827.32 IU/L vs. 2218.08 ± 2310.41 IU/L, p < 0.001) and CKmb (336.15 ± 195.08 mg/mL vs. 231.53 ± 179.53 mg/mL, p < 0.001) levels were higher for an IMR above the 30 group. The left ventricular ejection fraction (LVEF) (44.57 ± 6.685% vs. 47.35 ± 8.17%, p = 0.006) and improvement of LVEF (2.81 ± 7.135% vs. 5.88 ± 7.65%, p = 0.004) was lower in the IMR above 30 group. All-cause mortality (7.5% vs. 1.3%, p = 0.012) was higher in the IMR above 30 group, and a Cox regression analysis showed that an IMR above 30 was a poor prognostic factor regarding all-cause mortality (HR: 5.151, 95% CI 1.062–24.987, p = 0.042) even after adjusting for classical clinical risk factors. Conclusions: An elevated IMR value represented larger infarct size, more severe LV dysfunction, and higher mortality in LAD STEMI patients after successful PCI. Full article
(This article belongs to the Section Cardiology)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">
16 pages, 835 KiB  
Review
Plant Immunity against Tobamoviruses
by Xiyin Zheng, Yiqing Li and Yule Liu
Viruses 2024, 16(4), 530; https://doi.org/10.3390/v16040530 (registering DOI) - 29 Mar 2024
Abstract
Tobamoviruses are a group of plant viruses that pose a significant threat to agricultural crops worldwide. In this review, we focus on plant immunity against tobamoviruses, including pattern-triggered immunity (PTI), effector-triggered immunity (ETI), the RNA-targeting pathway, phytohormones, reactive oxygen species (ROS), and autophagy. [...] Read more.
Tobamoviruses are a group of plant viruses that pose a significant threat to agricultural crops worldwide. In this review, we focus on plant immunity against tobamoviruses, including pattern-triggered immunity (PTI), effector-triggered immunity (ETI), the RNA-targeting pathway, phytohormones, reactive oxygen species (ROS), and autophagy. Further, we highlight the genetic resources for resistance against tobamoviruses in plant breeding and discuss future directions on plant protection against tobamoviruses. Full article
Show Figures

Figure 1

Full article ">Full article ">
19 pages, 4737 KiB  
Article
SEB-YOLO: An Improved YOLOv5 Model for Remote Sensing Small Target Detection
by Yan Hui, Shijie You, Xiuhua Hu, Panpan Yang and Jing Zhao
Sensors 2024, 24(7), 2193; https://doi.org/10.3390/s24072193 (registering DOI) - 29 Mar 2024
Abstract
Due to the limited semantic information extraction with small objects and difficulty in distinguishing similar targets, it brings great challenges to target detection in remote sensing scenarios, which results in poor detection performance. This paper proposes an improved YOLOv5 remote sensing image target [...] Read more.
Due to the limited semantic information extraction with small objects and difficulty in distinguishing similar targets, it brings great challenges to target detection in remote sensing scenarios, which results in poor detection performance. This paper proposes an improved YOLOv5 remote sensing image target detection algorithm, SEB-YOLO (SPD-Conv + ECSPP + Bi-FPN + YOLOv5). Firstly, the space-to-depth (SPD) layer followed by a non-strided convolution (Conv) layer module (SPD-Conv) was used to reconstruct the backbone network, which retained the global features and reduced the feature loss. Meanwhile, the pooling module with the attention mechanism of the final layer of the backbone network was designed to help the network better identify and locate the target. Furthermore, a bidirectional feature pyramid network (Bi-FPN) with bilinear interpolation upsampling was added to improve bidirectional cross-scale connection and weighted feature fusion. Finally, the decoupled head is introduced to enhance the model convergence and solve the contradiction between the classification task and the regression task. Experimental results on NWPU VHR-10 and RSOD datasets show that the mAP of the proposed algorithm reaches 93.5% and 93.9%respectively, which is 4.0% and 5.3% higher than that of the original YOLOv5l algorithm. The proposed algorithm achieves better detection results for complex remote sensing images. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
25 pages, 6011 KiB  
Article
Tea-Derived Polyphenols Enhance Drought Resistance of Tea Plants (Camellia sinensis) by Alleviating Jasmonate–Isoleucine Pathway and Flavonoid Metabolism Flow
by Haoming Zuo, Jiahao Chen, Zhidong Lv, Chenyu Shao, Ziqi Chen, Yuebin Zhou and Chengwen Shen
Int. J. Mol. Sci. 2024, 25(7), 3817; https://doi.org/10.3390/ijms25073817 (registering DOI) - 29 Mar 2024
Abstract
Extreme drought weather has occurred frequently in recent years, resulting in serious yield loss in tea plantations. The study of drought in tea plantations is becoming more and more intensive, but there are fewer studies on drought-resistant measures applied in actual production. Therefore, [...] Read more.
Extreme drought weather has occurred frequently in recent years, resulting in serious yield loss in tea plantations. The study of drought in tea plantations is becoming more and more intensive, but there are fewer studies on drought-resistant measures applied in actual production. Therefore, in this study, we investigated the effect of exogenous tea polyphenols on the drought resistance of tea plant by pouring 100 mg·L−1 of exogenous tea polyphenols into the root under drought. The exogenous tea polyphenols were able to promote the closure of stomata and reduce water loss from leaves under drought stress. Drought-induced malondialdehyde (MDA) accumulation in tea leaves and roots was also significantly reduced by exogenous tea polyphenols. Combined transcriptomic and metabolomic analyses showed that exogenous tea polyphenols regulated the abnormal responses of photosynthetic and energy metabolism in leaves under drought conditions and alleviated sphingolipid metabolism, arginine metabolism, and glutathione metabolism in the root system, which enhanced the drought resistance of tea seedlings. Exogenous tea polyphenols induced jasmonic acid–isoleucine (JA-ILE) accumulation in the root system, and the jasmonic acid–isoleucine synthetase gene (TEA028623), jasmonic acid ZIM structural domain proteins (JAMs) synthesis genes (novel.22237, TEA001821), and the transcription factor MYC2 (TEA014288, TEA005840) were significantly up-regulated. Meanwhile, the flavonoid metabolic flow was significantly altered in the root; for example, the content of EGCG, ECG, and EGC was significantly increased. Thus, exogenous tea polyphenols enhance the drought resistance of tea plants through multiple pathways. Full article
(This article belongs to the Section Molecular Plant Sciences)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
21 pages, 4834 KiB  
Review
Progressive Age-Associated Blood–Brain Barrier Leak/Dysfunction-Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New Targets for Future Treatments
by Charles R. Joseph
Diagnostics 2024, 14(7), 726; https://doi.org/10.3390/diagnostics14070726 (registering DOI) - 29 Mar 2024
Abstract
This review article focuses on the upstream pertinent pathophysiology leading to neurodegenerative disease. Specifically, the nexus appears to be blood–brain barrier (BBB) leakiness resulting in a two-prong inflammatory disease spectrum damaging the microvasculature and corrupting protein synthesis and degradation with accumulating misfolded toxic [...] Read more.
This review article focuses on the upstream pertinent pathophysiology leading to neurodegenerative disease. Specifically, the nexus appears to be blood–brain barrier (BBB) leakiness resulting in a two-prong inflammatory disease spectrum damaging the microvasculature and corrupting protein synthesis and degradation with accumulating misfolded toxic proteins. The suboptimal results of removing misfolded proteins mean a new approach to disease in the preclinical state is required aimed at other targets. Validated noninvasive imaging and serologic biomarkers of early preclinical disease implemented in the high-risk patient cohort along with periodic surveillance once effective treatments are developed will be required. This review discusses the physiology and pathophysiology of the BBB, new MRI imaging techniques identifying the leak, and altered fluid dynamic effects in the preclinical state. The risk factors for disease development, preventative measures, and potential treatment targets are also discussed. Full article
(This article belongs to the Special Issue Advances in the Imaging of Stroke and Neurodegenerative Disorders)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
16 pages, 4137 KiB  
Article
Flow Pattern and Escape Hazards of People from Flood Intrusion into the Staircase of Underground Spaces with Multiple Rest Platforms
by Zhiyu Lin, Shengbin Hu and Hang Lin
Buildings 2024, 14(4), 941; https://doi.org/10.3390/buildings14040941 (registering DOI) - 29 Mar 2024
Abstract
While urban underground space is being built and developed at a high speed, urban flooding is also occurring gradually and frequently. Urban water, in many disasters, has intruded into underground spaces, such as subway stations, often leading to serious casualties, in which it [...] Read more.
While urban underground space is being built and developed at a high speed, urban flooding is also occurring gradually and frequently. Urban water, in many disasters, has intruded into underground spaces, such as subway stations, often leading to serious casualties, in which it is crucial for people to be able to escape from the staircases. In order to enable and guide the escape of people in underground floods, a staircase model with multiple rest platforms, applicable to common entrance and exit staircase forms, was constructed. The realizable k-ε turbulence model, coupled with a volume of fluid (VOF) method, was used to simulate and analyze the flow patterns when floods of various heights intrude into the structure. The effects of rest platform settings on the ejection phenomena and flow velocity changes in flood flows were summarized. The change rule of flood flow velocity on the stairs under different flood heights and stair heights was summarized, and a linear relationship between the peak flood flow velocity and the location of the peak flow velocity point on each flight of stairs was derived. Combined with the formula of the critical conditions for people to escape upwards in the flood, the proposed escape conditions for staircases with multiple rest platforms were proposed, which provide a basis for guiding the evacuation of people in times of disaster. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
12 pages, 721 KiB  
Article
Lipid Profile, Eating Habit, and Physical Activity in Children with Down Syndrome: A Prospective Study
by Luca Pecoraro, Melissa Zadra, Francesco Cavallin, Silvana Lauriola, Giorgio Piacentini and Angelo Pietrobelli
Diseases 2024, 12(4), 68; https://doi.org/10.3390/diseases12040068 (registering DOI) - 29 Mar 2024
Abstract
Children with Down Syndrome (DS) frequently undergo health challenges, including a higher prevalence of overweight and obesity. We aimed to evaluate the impact of dietary and physical advice provided by a specialized pediatrician over two years. In this prospective study, 44 children with [...] Read more.
Children with Down Syndrome (DS) frequently undergo health challenges, including a higher prevalence of overweight and obesity. We aimed to evaluate the impact of dietary and physical advice provided by a specialized pediatrician over two years. In this prospective study, 44 children with DS, aged 2 to 17, underwent outpatient follow-up visits every six months between December 2020 and May 2023. Dietary habits, physical activities, anthropometric data, and laboratory results were recorded at baseline and 2-year follow-up. Adherence to the Mediterranean diet and physical activity were investigated using the ‘KIDMED’ and ‘Godin–Shepard Leisure-Time’ questionnaires, respectively, completed by the parents of the children. Venous blood samples were taken to determine the lipid profile. A significant reduction in BMI z-scores (p = 0.006) and an improvement in Godin–Shepard questionnaire scores (p = 0.0004) were observed. On the other hand, the lipid profile worsened, with an increase in LDL-c (p = 0.04) and a decrease in HDL-c (p = 0.03). Children with DS may benefit from an educational program on nutrition and physical activity to optimize weight control. Different interventions should target the lipid profile. Preventive intervention and follow-up by the pediatrician are essential for DS, which should continue into adulthood. Full article
Show Figures

Figure 1

Full article ">Full article ">
12 pages, 977 KiB  
Article
Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults
by Seung-Woo Ryoo, Baek-Yong Choi, Seok-Yoon Son, Kun-Hee Oh, Jin-Young Min and Kyoung-Bok Min
Nutrients 2024, 16(7), 1001; https://doi.org/10.3390/nu16071001 (registering DOI) - 29 Mar 2024
Abstract
Many studies suggest a significant association between individual essential trace elements (ETEs) and cognitive impairment in older adults, but evidence of the synchronized effect of multiple ETEs on cognitive function is lacking. We investigated the association between multiple ETEs, cognitive impairment with no [...] Read more.
Many studies suggest a significant association between individual essential trace elements (ETEs) and cognitive impairment in older adults, but evidence of the synchronized effect of multiple ETEs on cognitive function is lacking. We investigated the association between multiple ETEs, cognitive impairment with no dementia (CIND), and executive function in older Korean adults, using the Bayesian kernel machine regression (BKMR) model. Three hundred and thirty-six older adults were included as the study population and classified as the CIND and control groups. Blood manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), and molybdenum (Mo) were measured as relevant ETEs. The frontal/executive tests included digit symbol coding (DSC), the Korean color word Stroop test (K-CWST), a controlled oral word association test (COWAT), and a trial-making test (TMT). Overall, the BKMR showed a negative association between multiple ETEs and the odds of CIND. Mn was designated as the most dominant element associated with the CIND (PIP = 0.6184), with a U-shaped relationship. Cu and Se levels were positively associated with the K-CWST percentiles (β = 31.78; 95% CI: 13.51, 50.06) and DSC percentiles (β = 25.10; 95% CI: 7.66, 42.53), respectively. Our results suggest that exposure to multiple ETEs may be linked to a protective mechanism against cognitive impairment in older adults. Full article
(This article belongs to the Section Micronutrients and Human Health)
Show Figures

Figure 1

Full article ">
14 pages, 1379 KiB  
Article
Judging Rainfall Intensity from Inter-Tip Times: Comparing ‘Straight-Through’ and Syphon-Equipped Tipping-Bucket Rain Gauge Performance
by David Dunkerley
Water 2024, 16(7), 998; https://doi.org/10.3390/w16070998 (registering DOI) - 29 Mar 2024
Abstract
The inter-tip times (ITTs) of tipping-bucket rain gauges (TBRGs) potentially provide the highest-resolution intensity data that can be acquired from this type of gauge. At an intensity of 100 mm h−1, a typical gauge with a sensitivity of 0.2 mm of [...] Read more.
The inter-tip times (ITTs) of tipping-bucket rain gauges (TBRGs) potentially provide the highest-resolution intensity data that can be acquired from this type of gauge. At an intensity of 100 mm h−1, a typical gauge with a sensitivity of 0.2 mm of rainfall would be expected to tip every 7.2 s. However, TBRGs are often equipped with syphons to reduce the dynamic calibration error that results from continued (and unmeasured) inflow to a bucket as it tips. This increases the accuracy of rainfall depth recording, but the time to fill and empty the syphon can reduce the ability of a TBRG to respond to (and for the ITTs to reflect) short-term intensity fluctuations. This ability is already limited by the discretisation arising from the filling and emptying of the buckets themselves. Laboratory tests with controlled water inflow rates were performed using two high-quality TBRGs, one a ‘straight-through’ design and the other syphon-equipped. These confirmed that at all intensities at which the syphon operates, a regular sequence of fixed-duration ITTs (such as the 7.2 s mentioned above) does not occur. Rather, the ITTs are perturbed by the syphon cycling. The gauges were also co-located in the field and linked to carefully synchronised event data loggers. Data collected during several rainfall events revealed differences in the ITTs and again confirm that the ITT sequence of a syphon-equipped TBRG exhibits artefacts related to syphon operation that are not present in the ‘straight-through’ data. These artefacts can result in ITT differences of many minutes, depending on the rainfall intensity and are problematic for the use of ITTs to estimate intensity. Peaks and troughs in the intensity profile also differed between the two gauges. It is recommended that in the application of TBRGs for studies where short-term intensity data are required, ‘straight-through’ gauges should be used, and syphon-equipped gauges should be avoided. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">
14 pages, 1046 KiB  
Review
The Impact of Essential Amino Acids on the Gut Microbiota of Broiler Chickens
by Thyneice Taylor-Bowden, Sarayu Bhogoju, Collins N. Khwatenge and Samuel N. Nahashon
Microorganisms 2024, 12(4), 693; https://doi.org/10.3390/microorganisms12040693 (registering DOI) - 29 Mar 2024
Abstract
The research involving the beneficial aspects of amino acids being added to poultry feed pertaining to performance, growth, feed intake, and feed conversion ratio is extensive. Yet currently the effects of amino acids on the gut microbiota aren’t fully understood nor have there [...] Read more.
The research involving the beneficial aspects of amino acids being added to poultry feed pertaining to performance, growth, feed intake, and feed conversion ratio is extensive. Yet currently the effects of amino acids on the gut microbiota aren’t fully understood nor have there been many studies executed in poultry to explain the relationship between amino acids and the gut microbiota. The overall outcome of health has been linked to bird gut health due to the functionality of gastrointestinal tract (GIT) for digestion/absorption of nutrients as well as immune response. These essential functions of the GI are greatly driven by the resident microbiota which produce metabolites such as butyrate, propionate, and acetate, providing the microbiota a suitable and thrive driven environment. Feed, age, the use of feed additives and pathogenic infections are the main factors that have an effect on the microbial community within the GIT. Changes in these factors may have potential effects on the gut microbiota in the chicken intestine which in turn may have an influence on health essentially affecting growth, feed intake, and feed conversion ratio. This review will highlight limited research studies that investigated the possible role of amino acids in the gut microbiota composition of poultry. Full article
(This article belongs to the Special Issue Gastrointestinal Microbiome in Animals)
Show Figures

Figure 1

Full article ">Full article ">
13 pages, 451 KiB  
Article
An Objective Function-Based Clustering Algorithm with a Closed-Form Solution and Application to Reference Interval Estimation in Laboratory Medicine
by Frank Klawonn and Georg Hoffmann
Algorithms 2024, 17(4), 143; https://doi.org/10.3390/a17040143 (registering DOI) - 29 Mar 2024
Abstract
Clustering algorithms are usually iterative procedures. In particular, when the clustering algorithm aims to optimise an objective function like in k-means clustering or Gaussian mixture models, iterative heuristics are required due to the high non-linearity of the objective function. This implies higher [...] Read more.
Clustering algorithms are usually iterative procedures. In particular, when the clustering algorithm aims to optimise an objective function like in k-means clustering or Gaussian mixture models, iterative heuristics are required due to the high non-linearity of the objective function. This implies higher computational costs and the risk of finding only a local optimum and not the global optimum of the objective function. In this paper, we demonstrate that in the case of one-dimensional clustering with one main and one noise cluster, one can formulate an objective function, which permits a closed-form solution with no need for an iteration scheme and the guarantee of finding the global optimum. We demonstrate how such an algorithm can be applied in the context of laboratory medicine as a method to estimate reference intervals that represent the range of “normal” values. Full article
(This article belongs to the Special Issue Nature-Inspired Algorithms in Machine Learning (2nd Edition))
Show Figures

Figure 1

Full article ">Full article ">Full article ">
10 pages, 240 KiB  
Article
Church Governance—A Philosophical Approach to a Theological Challenge in an Anglican Context
by Peter D. G. Richards
Religions 2024, 15(4), 427; https://doi.org/10.3390/rel15040427 (registering DOI) - 29 Mar 2024
Abstract
Church governance is not often debated within a philosophical or theological sphere. This is perhaps because church governance has been part of tradition since Constantine and the initial Greek philosophical world view of sovereignty and hierarchy. Such a stance has led towards a [...] Read more.
Church governance is not often debated within a philosophical or theological sphere. This is perhaps because church governance has been part of tradition since Constantine and the initial Greek philosophical world view of sovereignty and hierarchy. Such a stance has led towards a managerial mindset that follows and conforms to the world, which plays out within the Anglican polity in the setting of an adversarial parliamentary style synod. This style encourages bounded communities of power that often refute the burgeoning inspirations of the Spirit. In changing the underlying theological basis of such a stance, by invoking the understanding of an undeniable community in the singularity of the Triune God, governance becomes more open. Engaging with, primarily, Agamben but also others from philosophy, a new viewpoint is presented to challenge the manner through which tradition is wielded as the only possibility. In seeing through a differing lens, communities can be conceived as both porous and interconnected, thus allowing the body of Christ to respond with transformative action as opposed to a continuum of conformance with secular legality. In this manner, the bishop’s role may become more centralised towards a Eucharistic one, as opposed to the managerial mindset and role, to enhance the possibilities of God’s love. This then removes the need for a hierarchy driven by a sovereign mindset that tradition bolsters, whilst maintaining loving and authoritative oversight that tradition suggests. Full article
(This article belongs to the Special Issue Continental Philosophy and Christian Beliefs)
14 pages, 3956 KiB  
Article
Quality Evaluation and Identification of Phyllanthi fructus (Yuganzi) Based on the Spectrum-Effect Relationship
by Weiwei Zhou, Bencheng Wu, Ling Liu, Jun Li, Dongdong Shi and Xiumei Li
Separations 2024, 11(4), 104; https://doi.org/10.3390/separations11040104 (registering DOI) - 29 Mar 2024
Abstract
To establish a quality evaluation and identification method for Phyllanthi fructus (Yuganzi), the spectrum-effect relationship was explored. A high-performance liquid chromatography (HPLC) fingerprint was established using ultraviolet spectrophotometry, and the in vitro antioxidant activity was determined using a total antioxidant capacity assay kit. [...] Read more.
To establish a quality evaluation and identification method for Phyllanthi fructus (Yuganzi), the spectrum-effect relationship was explored. A high-performance liquid chromatography (HPLC) fingerprint was established using ultraviolet spectrophotometry, and the in vitro antioxidant activity was determined using a total antioxidant capacity assay kit. Similarity analysis, hierarchical cluster analysis (HCA), and partial least squares regression (PLSR) were performed to establish the spectrum-effect relationships. Thirteen batches of Yuganzi were collected for testing. The results revealed that the optimal chromatographic conditions for the HPLC fingerprint were as follows: the mobile phase consisted of 0.1% phosphoric acid solution (A) and acetonitrile (B), the detection wavelength was 214 nm, the column temperature was 30 °C, and the flow rate was 0.8 mL/min. Among the batches of samples, the similarity values of 10 samples (S1–S10) from Yunnan were larger than 0.995; the similarity values of 3 samples (S11–S13) from India, Gaoligong Mountain, and Fujian were less than or equal to 0.986. Furthermore, nineteen characteristic peaks of Yuganzi were calibrated using fingerprint evaluation software. The study on the spectrum-effect relationship further revealed that compounds corresponding to peaks 5 and 8 were potentially key ingredients for the quality evaluation and identification of Yuganzi, closely related to the stable antioxidant activities of Yuganzi. The spectrum-effect relationship is an agile and efficient approach that can ensure the intra-assay stability of Yuganzi from same region and identify Yuganzi from different regions. Compounds with antioxidant activity can be identified as quality markers for Yuganzi. Full article
(This article belongs to the Section Analysis of Natural Products and Pharmaceuticals)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
11 pages, 239 KiB  
Article
Association of Urine (pH < 5.5) with Community Periodontal Index (CPI) and the Number of Remaining Teeth in Korean Adults: A Cross-Sectional Study Using Data from Korea National Health and Nutrition Examination Survey 2016–2018
by Su-Yeon Hwang and Jung-Eun Park
Healthcare 2024, 12(7), 740; https://doi.org/10.3390/healthcare12070740 (registering DOI) - 29 Mar 2024
Abstract
This study aims to determine the association between UpH (<5.5), Community Periodontal Index (CPI), and the number of remaining teeth—cumulative indicators of oral health—using data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES, 2016–2018), which represents the Korean population. [...] Read more.
This study aims to determine the association between UpH (<5.5), Community Periodontal Index (CPI), and the number of remaining teeth—cumulative indicators of oral health—using data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES, 2016–2018), which represents the Korean population. Data from 12,689 adults aged 19 years and older who had periodontal examinations were analyzed. Logistic regression analysis was performed after adjusting for demographic, health, and health-related behavioral factors as covariates to determine the association between UpH, CPI, and the number of remaining teeth. This study found that UpH (<5.5) was associated with CPI and the number of remaining teeth. For UpH (<5.5), the odds ratio for CPI (≥4 mm) was 1.19 times (95% CI: 1.06–1.33). The risk of tooth loss was 1.25 times (95% CI: 1.06–1.48) for those with 0–19 remaining teeth and 1.20 times (95% CI: 1.07–1.34) for those with 20–27 teeth. The results revealed an association between UpH, CPI, and the number of remaining teeth. However, further longitudinal research on UpH and oral status is necessary. Full article
(This article belongs to the Special Issue Oral Health Care and Services for Patients)
15 pages, 3045 KiB  
Article
Transport Model of Rare Earth Elements in Weathering Crusts during Electrokinetic Mining
by Gaofeng Wang, Bowen Ling, Xiaoliang Liang, Jie Xu, Shichang Kang, Jingming Wei, Wei Tan, Runliang Zhu, Jianxi Zhu and Hongping He
Minerals 2024, 14(4), 360; https://doi.org/10.3390/min14040360 (registering DOI) - 29 Mar 2024
Abstract
Electrokinetic mining (EKM) is a novel method for rare earth element (REE) mining that can achieve green and efficient recovery of REEs. However, as yet, there is no accurate model for describing the electrokinetic transport of REEs in weathering crusts, and this hinders [...] Read more.
Electrokinetic mining (EKM) is a novel method for rare earth element (REE) mining that can achieve green and efficient recovery of REEs. However, as yet, there is no accurate model for describing the electrokinetic transport of REEs in weathering crusts, and this hinders the wider application of EKM. The conventional model fails to capture the microscale transport physics occurring in the nanochannels that exist ubiquitously in weathering crusts. Consequently, the existing models cannot distinguish the mobilities of different REEs. Here, we report a new model for a more faithful description of the electrokinetic transport of REEs in weathering crusts that considers the ionic size, which has previously been neglected. We reveal that the electrokinetic transport of heavy REEs (HREEs) is faster than that of light REEs (LREEs) in weathering crusts, which is contrary to the predictions of conventional models. Our model was validated experimentally by measurements of the electrokinetic transport of two LREEs (La and Sm) and an HREE (Er) in weathering crusts. The speed of electrokinetic transport follows the order Er > Sm > La. Our findings suggest that the ionic size is a non-negligible factor affecting the electrokinetic transport of REEs in weathering crusts containing nanochannels. This work offers a constitutive model to describe the electrokinetic transport of REEs in weathering crusts, which promotes both theoretical developments and practical applications of EKM. Full article
(This article belongs to the Special Issue Green and Efficient Recovery/Extraction of Rare Earth Resources)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">Full article ">
15 pages, 4489 KiB  
Article
Influence of the Long-Term Application of Management Practices (Tillage, Cover Crop and Glyphosate) on Greenhouse Gas Emissions and Soil Physical Properties
by Modupe Olufemi Doyeni, Skaidre Suproniene, Agne Versuliene, Loreta Meskauskiene and Grazina Kadziene
Sustainability 2024, 16(7), 2859; https://doi.org/10.3390/su16072859 (registering DOI) - 29 Mar 2024
Abstract
Soil treatments have a significant influence on the agricultural and environmental productivity of agricultural practices. Arable lands are one of the sources of greenhouse gas emissions (GHG) that are influenced by the chemical and physical properties of the soil and are an essential [...] Read more.
Soil treatments have a significant influence on the agricultural and environmental productivity of agricultural practices. Arable lands are one of the sources of greenhouse gas emissions (GHG) that are influenced by the chemical and physical properties of the soil and are an essential contributor to climate change. We aim to evaluate the long-term management of agricultural practices, such as different tillage systems, cover crops, and glyphosate, on GHG emissions and soil physical properties. The field trial involved three tillage systems (conventional tillage (CT), reduced tillage (RT), and no-tillage (NT)), along with variations in cover cropping (with and without cover crops) and glyphosate application (with and without glyphosate). These treatments were implemented during the cultivation of oilseed rape in 2022 as part of a cropping sequence consisting of five crops: winter wheat; winter oilseed rape; spring wheat; spring barley; and field pea. Greenhouse gas emissions (carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O)) were directly measured using a closed static chamber system. Through the examination of these management techniques, the soil’s physical properties over the studied period were assessed for their impact on GHG fluxes. The findings of the study reveal that N2O emissions were relatively low during the first month of measurement, with significant differences (p < 0.05) observed in the interaction between cover crop and glyphosate treatments. Additionally, N2O emissions were notably elevated in the reduced (0.079 µg m−2 h−1) and conventional tillage (0.097 µg m−2 h−1) treatments at the second month of measurement. Regarding CH4, increased emissions were observed in the reduced tillage and cover crop treatments. CO2 emissions exhibited variability across all of the investigated treatments. Notably, GHG fluxes spiked at the second measurement, signifying the maximum uptake of nutrients by the main plants during the growth phase. Greenhouse gas emissions leveled off across all of the treatments following the harvest, marking the end of the cultivation period. The influence of the deployed techniques varied across the determined physical parameters of the soil. The incorporation of cover crops contributed to improved water content and, further, to electrical conductivity. Glyphosate use showed no direct impact on physical properties of the soil while the different tillage treatments had varying effects on the distribution of the physical properties of the soil with respect to the degree of disturbance or tillage-induced changes. Additionally, GHG emissions were strongly correlated with precipitation at one week and two weeks before sampling, except for CO2, which showed a weaker correlation at two weeks before GHG sampling. The findings indicate that reduced and conventional tillage methods might adversely affect greenhouse gas emissions and plant functionality, particularly concerning nutrient release and uptake, especially in temperate climate conditions. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">
15 pages, 1020 KiB  
Review
Lower Urinary Tract Infections: An Approach for Greek Community Health Practitioners
by Diamantis Klimentidis and Georgios Pappas
Acta Microbiol. Hell. 2024, 69(2), 50-64; https://doi.org/10.3390/amh69020007 (registering DOI) - 29 Mar 2024
Abstract
Urinary tract infections (UTIs) cause a significant infectious burden in the community and demand a coordinated approach from all first-line health professionals. Uncomplicated UTIs refer to infections in non-pregnant females without any underlying localized or generalized pathology, diagnosed through history by the presence [...] Read more.
Urinary tract infections (UTIs) cause a significant infectious burden in the community and demand a coordinated approach from all first-line health professionals. Uncomplicated UTIs refer to infections in non-pregnant females without any underlying localized or generalized pathology, diagnosed through history by the presence of specific local symptoms and in the absence of systemic ones like fever. Uncomplicated UTIs are usually caused by Escherichia coli species; thus, empirical antibiotic treatment can be immediately initiated. A percentage of patients can experience a resolution of symptoms without therapy; however, this “wait and observe” approach is supported only by the relevant British guidelines. There are limited quality studies in the literature on adjuvant treatment options; these can include BNO 145, a phytotherapeutic medicine, and XHP, a medical technology product. Despite being licensed by the European Medicines Agency on the basis of traditional use, there is inadequate support in the medical literature for the use of cranberry extracts and Arctostaphylos uva-ursi extracts. The use of antibiotics is associated with higher response rates and urine culture sterilization as well as lower recurrence/relapse rates; on the other hand, side effect rates are also higher. In choosing the proper empirical antibiotic therapy, one has to take into account individual patient characteristics and community resistance patterns as well as the antimicrobial resistance pressure exerted by the wide use of a specific antibiotic. There is a need for a common framework through which all frontline health practitioners should operate when faced with a case of uncomplicated UTI. In Greece, there are three different guidelines for UTI treatment, developed by the Ministry of Health, the National Organization for Medicines, and the Hellenic Society for Infectious Diseases. The authors of the present study aim at synthesizing these guidelines as well as relevant guidelines from international scientific or other national regulatory organizations while taking into account local resistance patterns. The authors propose the first-line use of either fosfomycin, nitrofurantoin, or pivmecillinam. The use of trimethoprim/sulfamethoxazole is discouraged due to increased resistance of Greek community E. coli isolates. Fluoroquinolone use should be avoided due to high E. coli community resistance (exceeding 20% for Greece), along with their unfavorable benefit/side effect balance in uncomplicated UTIs, as well as the overall community resistance pressure exerted by their use. A 5-day regimen remains superior to a 3-day one; the latter may be suitable for certain, not yet adequately characterized, patients. Full article
(This article belongs to the Special Issue Feature Papers in Medical Microbiology in 2024)
Show Figures

Figure 1

Full article ">
11 pages, 1257 KiB  
Article
Sensor-Based Quantitative Assessment of Children’s Fine Motor Competence: An Instrumented Version of the Placing Bricks Test
by Maria Cristina Bisi and Rita Stagni
Sensors 2024, 24(7), 2192; https://doi.org/10.3390/s24072192 (registering DOI) - 29 Mar 2024
Abstract
The assessment of fine motor competence plays a pivotal role in neuropsychological examinations for the identification of developmental deficits. Several tests have been proposed for the characterization of fine motor competence, with evaluation metrics primarily based on qualitative observation, limiting quantitative assessment to [...] Read more.
The assessment of fine motor competence plays a pivotal role in neuropsychological examinations for the identification of developmental deficits. Several tests have been proposed for the characterization of fine motor competence, with evaluation metrics primarily based on qualitative observation, limiting quantitative assessment to measures such as test durations. The Placing Bricks (PB) test evaluates fine motor competence across the lifespan, relying on the measurement of time to completion. The present study aims at instrumenting the PB test using wearable inertial sensors to complement PB standard assessment with reliable and objective process-oriented measures of performance. Fifty-four primary school children (27 6-year-olds and 27 7-year-olds) performed the PB according to standard protocol with their dominant and non-dominant hands, while wearing two tri-axial inertial sensors, one per wrist. An ad hoc algorithm based on the analysis of forearm angular velocity data was developed to automatically identify task events, and to quantify phases and their variability. The algorithm performance was tested against video recordings in data from five children. Cycle and Placing durations showed a strong agreement between IMU- and Video-derived measurements, with a mean difference <0.1 s, 95% confidence intervals <50% median phase duration, and very high positive correlation (ρ > 0.9). Analyzing the whole population, significant differences were found for age, as follows: six-year-olds exhibited longer cycle durations and higher variability, indicating a stage of development and potential differences in hand dominance; seven-year-olds demonstrated quicker and less variable performance, aligning with the expected maturation and the refined motor control associated with dominant hand training during the first year of school. The proposed sensor-based approach allowed the quantitative assessment of fine motor competence in children, providing a portable and rapid tool for monitoring developmental progress. Full article
(This article belongs to the Special Issue Movement Biomechanics Applications of Wearable Inertial Sensors)
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">
17 pages, 13202 KiB  
Article
The Bacterial and Fungal Compositions in the Rhizosphere of Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. in a Typical Planting Region
by Fuqi Wang, Zilu Zhao, Yangyang Han, Shiying Li, Xinhua Bi, Shumeng Ren, Yingni Pan, Dongmei Wang and Xiaoqiu Liu
Microorganisms 2024, 12(4), 692; https://doi.org/10.3390/microorganisms12040692 (registering DOI) - 29 Mar 2024
Abstract
Asarum is a traditional Chinese medicinal plant, and its dried roots are commonly used as medicinal materials. Research into the traits of the bacteria and fungus in the Asarum rhizosphere and how they relate to the potency of medicinal plants is important. During [...] Read more.
Asarum is a traditional Chinese medicinal plant, and its dried roots are commonly used as medicinal materials. Research into the traits of the bacteria and fungus in the Asarum rhizosphere and how they relate to the potency of medicinal plants is important. During four cropping years and collecting months, we used ITS rRNA gene amplicon and sequencing to assess the population, diversity, and predominant kinds of bacteria and fungus in the rhizosphere of Asarum. HPLC was used to determine the three bioactive ingredients, namely asarinin, aristolochic acid I, and volatile oil. The mainly secondary metabolites of Asarum, relationships between microbial communities, soil physicochemical parameters, and possible influences on microbial communities owing to various cropping years and collecting months were all statistically examined. The cropping years and collecting months affected the abundance and diversity of rhizosphere bacteria and fungi, but the cropping year had a significant impact on the structures and compositions of the bacterial communities. The rhizosphere microorganisms were influenced by both the soil physicochemical properties and enzyme activities. Additionally, this study revealed that Trichoderma was positively correlated with the three bioactive ingredients of Asarum, while Tausonia showed entirely opposite results. Gibberella and Leptosphaeria demonstrated a significantly negative correlation with asarinin and violate oil, but they were weakly correlated with the aristolochic acid I content. This study revealed variations in the Asarum rhizosphere microorganism population, diversity, and dominant types across four cropping years and collecting months. The relationship between Asarum secondary metabolites, the soil physicochemical properties, enzyme activities, and rhizosphere microorganisms was discussed. Our results will guide the exploration of the soil characteristics and rhizosphere microorganisms’ structures by regulating the microbial community to enhance Asarum quality. Full article
Show Figures

Figure 1

Full article ">Full article ">Full article ">Full article ">Full article ">
15 pages, 1500 KiB  
Review
Spirulina (Arthrospira platensis): Antiallergic Agent or Hidden Allergen? A Literature Review
by Weronika Gromek, Natalia Ko?dej, Marcin Kurowski and Emilia Majsiak
Foods 2024, 13(7), 1052; https://doi.org/10.3390/foods13071052 (registering DOI) - 29 Mar 2024
Abstract
Presently, there has been an increase in the consumption of the blue–green microalga–spirulina (Arthrospira species), which dominates 99.5% of the total world production of microalgae. Primarily sold as a dietary supplement, it is also incorporated into snacks, pasta, cookies, and bread. Owing [...] Read more.
Presently, there has been an increase in the consumption of the blue–green microalga–spirulina (Arthrospira species), which dominates 99.5% of the total world production of microalgae. Primarily sold as a dietary supplement, it is also incorporated into snacks, pasta, cookies, and bread. Owing to its nutrient abundance, spirulina has a variety of potential applications. Extensive studies have been conducted on the health benefits of spirulina, but its safety in terms of allergy has received limited attention. Therefore, to bridge this knowledge deficit, this review aimed to evaluate the allergenic and antiallergic potential of spirulina. In the PubMed and Scopus databases using words related to allergy, we attempted to detect papers on hypersensitivity to spirulina. A total of 128 records were identified, of which 49 were screened. Ultimately, in this review, we analyzed four case studies, encompassing a total of five patients with allergies to spirulina. We assessed the severity of allergic reactions following World Allergy Organization (WAO) Anaphylaxis Guidance 2020, which varied from mild (grade 2) to severe (grade 4) based on the patient’s symptoms. Additionally, our findings indicate that allergy to spirulina is not commonly reported or diagnosed. However, most of the described cases (four of five) regarding allergy to spirulina according to WAO Anaphylaxis Guidance 2020 were classified as anaphylaxis. Furthermore, it is noteworthy that spirulina also possesses antiallergic properties, as evidenced by research studies. Our article delves into both the allergic and antiallergic potential of spirulina. Full article
Show Figures

Figure 1

Full article ">Full article ">
15 pages, 808 KiB  
Review
Sex Differences in Cognitive Reflection: A Meta-Analysis
by Inmaculada Otero, Alexandra Martínez, Dámaris Cuadrado, Mario Lado, Silvia Moscoso and Jesús F. Salgado
J. Intell. 2024, 12(4), 39; https://doi.org/10.3390/jintelligence12040039 (registering DOI) - 29 Mar 2024
Abstract
The current study presents a meta-analytic review of the differences between men and women in cognitive reflection (CR). The study also explores whether the type of CR test (i.e., numerical tests and verbal tests) moderates the relationship between CR and sex. The results [...] Read more.
The current study presents a meta-analytic review of the differences between men and women in cognitive reflection (CR). The study also explores whether the type of CR test (i.e., numerical tests and verbal tests) moderates the relationship between CR and sex. The results showed that men score higher than women on CR, although the magnitude of these differences was small. We also found out that the type of CR test moderates the sex differences in CR, especially in the numerical tests. In addition, the results showed that the length of numerical tests (i.e., number of items) does not affect the differences between men and women in CR. Finally, the implications of these results are discussed, and future research is suggested. Full article
Show Figures

Figure 1

Full article ">

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news
news